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The present study was performed to investigate the prognostic value of plasma interleukin-6 (IL-6) concentrations and promoter polymorphisms of the IL-6 gene in patients with acute myocardial infarction treated with thrombolysis. Two hundred and eight patients with myocardial infarction treated with thrombolysis were included and followed for 2-5 years. Plasma concentrations of IL-6 were measured at admission and 48 h after admission. Genotyping for the -174 G > C and -572 G > C IL-6 polymorphisms was performed. Patients who died of cardiovascular causes or suffered a new myocardial infarction during follow-up had increased plasma concentrations of IL-6 at admission (P < 0.002) and at 48 h after admission (P < 0.05) compared with patients who had an uneventful course. IL-6 levels above the median at admission were independently associated with a worse prognosis. No associations were found between IL-6 levels and the promoter polymorphisms. The -174 G > C polymorphism was not associated with cardiovascular death or a new myocardial infarction, whereas the -572 G > C polymorphism showed a borderline significant increase in risk (P = 0.05) in univariate analysis. In conclusion, the early IL-6 response during myocardial infarction is associated with prognosis in patients with Q-wave myocardial infarction, whereas no associations were found between IL-6 genotype and phenotype.

Original publication

DOI

10.1016/j.atherosclerosis.2004.01.019

Type

Journal article

Journal

Atherosclerosis

Publication Date

05/2004

Volume

174

Pages

157 - 163

Keywords

Aged, Biomarkers, C-Reactive Protein, Cohort Studies, Confidence Intervals, Creatine Kinase, Female, Genetic Markers, Heart Function Tests, Hemodynamics, Humans, Interleukin-6, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction, Polymorphism, Genetic, Probability, Prognosis, Promoter Regions, Genetic, Proportional Hazards Models, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index, Survival Rate, Thrombolytic Therapy