DPHIL PROJECTS AVAILABLE
Associate Professor of Genomics
- MRC Clinician Scientist
- Honorary Consultant Haematologist
I am a clinician scientist with a specialist interest in haemopoietic stem cell transplantation, genome editing, genomics and bioinformatics. I studied medicine at Oxford University before going on to complete specialist training in haematology and intensive care medicine in London. I have an MRC Clinician Scientist Fellowship and my group is based at the MRC Weatherall Institute of Molecular Medicine. In addition, I am an honorary consultant haematologist with the allogeneic transplant service in Oxford.
My research focuses on developing novel next generation sequencing-based methods for interrogating how the genome functions and leveraging this to develop methods of genome editing bone marrow derived stem cells. I have a particular interest in developing methods that allow the physical structure of DNA in the nucleus to be defined. The way in which chromatin is folded is one of the key determinants of gene expression. We leverage our understanding of how the genome functions to develop novel strategies of editing blood and bone marrow derived cells to treat human disease. In particular, we are interested in using our expertise in developing high throughput sequencing assays and bioinformatics to develop new ways of defining the off-target effects caused by genome editing.
The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.
Hua P. et al, (2020), Blood
CaptureCompendium: a comprehensive toolkit for 3C analysis
Telenius J. et al, (2020)
Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.
Hua P. et al, (2019), Blood, 134, 2111 - 2115
BET inhibition disrupts transcription but retains enhancer-promoter contact
Crump N. et al, (2019)
An integrated platform to systematically identify causal variants and genes for polygenic human traits
Downes D. et al, (2019)