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Prof Patrik Rorsman, Professor of Diabetic Medicine at OCDEM and Prof Raj Thakker, May Professor of Medicine at OCDEM have both been elected as Fellows of the Royal Society, in recognition of their scientific achievements.

Royal society crest
The Royal Society

Prof Rorsman has made distinguished contributions to our understanding of how the insulin- and glucagon-producing cells of the pancreatic islets regulate the plasma glucose concentration. His pioneering work is a shining example of post-genomic experimental diabetes research that integrates an unusual breadth of sophisticated methods and has clinical implications. It has led to the identification of key processes that become disrupted in type 2 diabetes, and shed light on the causal relationship between obesity and diabetes.

Prof Thakker has made a sustained series of major contributions to endocrinology, particularly parathyroid and renal disorders affecting calcium homeostasis. His research at the basic-science and clinical interface has resulted in seminal gene discoveries and insights into molecular, cellular and physiological mechanisms. These include: identification of functional pathways of calcium-sensing, through characterisation of mutations of the calcium-sensing-receptor, a G-protein-coupled- receptor (GPCR), and its signalling pathway through G-protein-alpha-11-subunit (Gα11) and adaptor-protein-2-sigma-subunit (AP2σ), which regulates GPCR endocytosis; and defining a molecular-based taxonomy of syndromic and non-syndromic hyperparathyroid and hypoparathyroid disorders that has resulted in new pathophysiological insights and advances in diagnosis and treatment.

"This is a huge achievement for Profs Rorsman and Thakker, and a well-deserved recognition of their pioneering work" said Prof Hugh Watkins, Head of RDM.

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