Using a computer based (in silico) meta-analysis approach the researchers defined a transcriptional programme underlying angiogenesis in human cancer. They identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signalling. In multiple cancer types, a significant upregulation of ELTD1 is seen in tumour-associated endothelial cells. Silencing of ELTD1 impairs endothelial sprouting and vessel formation in vitro and in vivo, drastically reducing tumour growth and greatly improving survival. Clinically ELTD1 represents an important candidate for targeted antiangiogenic approaches.
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