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Cardiovascular and Metabolic Medicine

Clinician in clinic with participant, setting up to use exercise bike

We investigate the mechanisms involved in maintaining health across all cells and tissues relevant to cardiovascular, neurovascular and metabolic diseases, to advance diagnosis, prevention and treatment. 

Strong in discovery science

Track record in translation and clinical trials

Capabilities in clinical imaging

OUR Research questions

  1. What are the shared mechanisms that drive multi-morbid cardiovascular and metabolic disease? 
  2. How can we harness innovative methods such as AI to improve scientific insight into disease and patient outcomes?
  3. How do modifiable risk factors interact and contribute to cardiometabolic disease pathogenesis?
  4. How can we improve the discovery and translation of innovative approaches to treat cardiometabolic disease?

Our Research Groups

Three panel image: panel 1 shows an illustration of a cell with specific proteins on cell surface, a blow up of the lipid bilayers, and miRNAs, DNA and metabolites inside the cells; the second panel is a electron microscopy images of cells, and the third is a dot graph showing data for groups at presentation and followup, which shows two distinct groups at these two time points.

Akbar Group: Extracellular Vesicles in Cardiovascular, Inflammatory and Metabolic Disease

Selection of images from Antoniades' Group

Antoniades Group: The Oxford Translational Cardiovascular Research Group

Human atrial fibroblast stained for Filamin A and Calcitonin Receptor (curtesy to Aaron Johnston).

Reilly Group: Atrial Fibrillation and Cardiac Fibrosis: from molecular signalling to drug discovery

Banning Group

Betts Group: Cardiac Rhythm Management

Bhattacharya Group: Developing novel therapeutics for inflammatory diseases

Channon Group: Cardiovascular functional genomics and redox signalling

Choudhury Group: Understanding Inflammatory processes in Atherosclerosis and Acute Myocardial Infarction

Adipose tissue illustration

Christodoulides Group: Adipose Biology and Metabolic Disease

An MRI scanner in OCMR.

Ferreira Group: Quantitative cardiac magnetic resonance myocardial tissue characterisation

Goel Group: Cardiovascular genetics and bioinformatics

MRI Image of brain

Grist Group: Clinical Neuroimaging

Hodson Group: Cellular Metabolism and GPCR Signalling

Hodson Group: Human in vivo and in vitro lipid metabolism

Metabolically healthy and unhealthy obesity (scans)

Karpe Group

Small vessel images taken by a VITA device show clear differences between a healthy participant and a participant with cardiovascular risk factors and worse brain health.

Lapidaire Group: Brain Health Vascular Imaging

Leeson Group: Preventive Cardiology Research Group

Lewis Group: Spatial Cardiology

Translucent 3D rendering of the heart, demonstrating the 4 heart valves

Myerson Group: Heart Valve Disease

Nasteska Group: Islet Protein Turnover

MRI scanner with patient, consultant and radiographer.

Neubauer Group: Oxford Centre for Clinical Magnetic Resonance Research

Composite image of MRI images

Pavlides Group: Quantitative MR and liver disease

Piechnik Group: Myocardial functional T1 mapping – Advanced cardiac magnetic resonance imaging techniques

Ray Group

Redwood Group: Cardiac Contractility

Rider Group: Obesity, Heart Failure, Linking Myocardial Metabolism and Function

Rorsman Group

Thakker Group: Academic Endocrine Unit

Fixed site lithotripter (Storz SLX-F2) which is permanently on site to treat stones

The Oxford Stone Group

Toepfer Group: Cardiac Physiology and Disease Modeling

Understanding metabolic function in liver, fat and muscle.

Tomlinson Group: Metabolism and Steroid Hormone Biology

Metabolic images of the conversion of hyperpolarized pyruvate into bicarbonate and lactate in the normal and infarcted heart. A/F show standard proton images of the perfused heart, B/G show late gadolinium images highlighting the infarct area with a region of hypointensity, C/H show the distribution of the infused hyperpolarized pyruvate whilst D/I and E/J show the distribution of bicarbonate and lactate respectively. An area of reduced bicarbonate and enhanced lactate signal can be seen in the region of the infarct.

Tyler Group

Tzima Group: Mechanotransduction Group

Valkovič Group: Body MRS Group

Watkins Group: Inherited Heart Muscle Disease Group

Zhang Group: Artificial Intelligence in Cardiovascular Medicine