Nasteska Group: Islet Protein Turnover
- Cardiovascular and Metabolic Medicine
- Oxford Centre for Diabetes, Endocrinology and Metabolism
Bringing the focus back on protein synthesis in islets
As a fundamental process, protein synthesis in pancreatic beta cells sustains their structure and function. Our research project explores protein synthesis dynamics in pancreatic islets over time and across beta cell population, searching for subpopulations with differential synthesis. The study aims to clarify the mechanisms that define total protein turnover, thus widening T2D treatment options with drugs modulating protein synthesis and ultimately beta cell function and survival.
Our team
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Daniela Nasteska
Diabetes UK RD Lawrence Fellow
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Lewis Blincowe
Research Technician
Collaborators
- David Hodson, University of Oxford
- Ildem Akerman, University of Birmingham
- Srikeertnana Kuchi, University of Minnesota