Publications — Radcliffe Department of Medicine

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Processing single-cell RNA-seq datasets using SingCellaR.

Wang G. et al, (2022), STAR Protoc, 3

CD34+CD19-CD22+ B-cell progenitors might underlie phenotypic escape in patients treated with CD19-directed therapies.

Bueno C. et al, (2022), Blood

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.

Neo WH. et al, (2021), Nat Commun, 12

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development.

Roy A. et al, (2021), Cell Rep, 36

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia.

Iskander D. et al, (2021), Sci Transl Med, 13

The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell-lines.

Lines KE. et al, (2021), J Mol Endocrinol

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None. et al, (2021)

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cells

ROY A. et al, (2021), bioRxiv

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2021), J Exp Med, 218

Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia

Iskander D. et al, (2020), BLOOD, 136

Erratum: Functional annotation of human long noncoding RNAs via molecular phenotyping (Genome Research (2020) 30 (1060-1072) DOI: 10.1101/gr.254219.119)

Ramilowski JA. et al, (2020), Genome Research, 30

VALERIE: Visual-based inspection of alternative splicing events at single-cell resolution.

Wen WX. et al, (2020), PLoS Comput Biol, 16

SINGLE-CELL MULTI-OMIC ANALYSIS UNRAVELS GENETIC AND MOLECULAR HETEROGENEITY IN TRANSFORMED MYELOPROLIFERATIVE NEOPLASMS

Rodriguez-Meira A. et al, (2020), EXPERIMENTAL HEMATOLOGY, 88, S48 - S48

Functional annotation of human long noncoding RNAs via molecular phenotyping

Ramilowski JA. et al, (2020), Genome Research, 30, 1060 - 1072

SINGLE-CELL MULTI-OMICS REVEALS ABERRANT MEGAKARYOCYTE-PROGENITOR (MKP) SUB-FRACTIONS IN MYELOFIBROSIS (MF) AND IDENTIFIES MUTANT CLONE-SPECIFIC TARGETS

PSAILA B. et al, (2020), HemaSphere, 4, 1 - 1168

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.

Di Genua C. et al, (2020), Cancer Cell, 37, 690 - 704.e8

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Psaila B. et al, (2020), Mol Cell, 78, 477 - 492.e8

The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission.

Jeanpierre S. et al, (2020), Haematologica, 106, 111 - 122

Technological advances and computational approaches for alternative splicing analysis in single cells.

Wen WX. et al, (2020), Comput Struct Biotechnol J, 18, 332 - 343

Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.

Hua P. et al, (2019), Blood, 134, 2111 - 2115

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