Publications — Radcliffe Department of Medicine

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Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism.

Pham VN. et al, (2023), Science, 382

Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.

Wang M. et al, (2023), Mol Cell

A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.

Wit N. et al, (2023), Sci Adv, 9

Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links.

Morton SB. et al, (2022), Journal of the American Chemical Society

Genotoxic aldehydes in the hematopoietic system.

Wang M. et al, (2022), Blood

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.

Mulderrig L. et al, (2021), Nature, 600, 158 - 163

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9

Amino acid dependent formaldehyde metabolism in mammals

Pietzke M. et al, (2020), Communications Chemistry, 3

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.

Hodskinson MR. et al, (2020), Nature, 579, 603 - 608

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Alcón P. et al, (2020), Nat Struct Mol Biol, 27, 240 - 248

Structure of the Fanconi anaemia monoubiquitin ligase complex.

Shakeel S. et al, (2019), Nature, 575, 234 - 237

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

Bauer MR. et al, (2019), Future Med Chem, 11, 2491 - 2504

TRAIP is a master regulator of DNA interstrand crosslink repair.

Wu RA. et al, (2019), Nature, 567, 267 - 272

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.

Baud MGJ. et al, (2018), Eur J Med Chem, 152, 101 - 114

Increased formate overflow is a hallmark of oxidative cancer.

Meiser J. et al, (2018), Nat Commun, 9

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Garaycoechea JI. et al, (2018), Nature, 553, 171 - 177

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.

Burgos-Barragan G. et al, (2017), Nature, 548, 549 - 554

Of sizzling steaks and DNA repair.

Dingler FA. and Patel KJ., (2017), Science, 357, 130 - 131

Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells.

Bruemmer KJ. et al, (2017), J Am Chem Soc, 139, 5338 - 5350

A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells

Brewer TF. et al, (2017), Chemical Science, 8, 4073 - 4081

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