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Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

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Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9

Amino acid dependent formaldehyde metabolism in mammals

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Pietzke M. et al, (2020), Communications Chemistry, 3

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.

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Hodskinson MR. et al, (2020), Nature, 579, 603 - 608

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

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Alcón P. et al, (2020), Nat Struct Mol Biol, 27, 240 - 248

Structure of the Fanconi anaemia monoubiquitin ligase complex.

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Shakeel S. et al, (2019), Nature, 575, 234 - 237

TRAIP is a master regulator of DNA interstrand crosslink repair.

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Wu RA. et al, (2019), Nature, 567, 267 - 272

Increased formate overflow is a hallmark of oxidative cancer.

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Meiser J. et al, (2018), Nat Commun, 9

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

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Garaycoechea JI. et al, (2018), Nature, 553, 171 - 177

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.

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Burgos-Barragan G. et al, (2017), Nature, 548, 549 - 554

Of sizzling steaks and DNA repair.

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Dingler FA. and Patel KJ., (2017), Science, 357, 130 - 131

Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells.

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Bruemmer KJ. et al, (2017), J Am Chem Soc, 139, 5338 - 5350

A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells

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Brewer TF. et al, (2017), Chemical Science, 8, 4073 - 4081

Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium.

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Pontel LB. et al, (2016), J Cell Sci, 129, 4449 - 4454

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

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Pontel LB. et al, (2015), Mol Cell, 60, 177 - 188

Do mutational dynamics in stem cells explain the origin of common cancers?

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Crossan GP. et al, (2015), Cell Stem Cell, 16, 111 - 112

Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage.

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Gibbs-Seymour I. et al, (2015), Mol Cell, 57, 150 - 164

Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases.

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Rajendra E. et al, (2014), Nucleic Acids Res, 42, 13736 - 13748

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

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Oberbeck N. et al, (2014), Mol Cell, 55, 807 - 817

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