Publications — Radcliffe Department of Medicine

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Oxidation of dietary linoleate occurs to a greater extent than dietary palmitate in vivo in humans.

Parry SA. et al, (2020), Clin Nutr

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Hastoy B. et al, (2018), Sci Rep, 8

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK. et al, (2018), Nat Genet, 50, 1122 - 1131

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci.

Thurner M. et al, (2018), Elife, 7

Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells.

Thurner M. et al, (2017), Stem Cell Reports, 9, 1395 - 1405

A HISTOLOGICAL AND BIOCHEMICAL ASSESSMENT OF STEATOTIC LIVERS UNDERGOING NORMOTHERMIC MACHINE PERFUSION

Ceresa C. et al, (2017), TRANSPLANT INTERNATIONAL, 30, 43 - 43

Effect of Normothermic Machine Perfusion on Outcomes after Steatotic Liver Transplantation: A First Assessment

Ceresa CDL. et al, (2017), TRANSPLANTATION, 101, 161 - 162

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.

Thomsen SK. et al, (2016), Diabetes, 65, 3805 - 3811

Prioritising causal genes at type 2 diabetes risk loci through high-throughput screening for human beta cell dysfunction

Thomsen SK. et al, (2016), DIABETOLOGIA, 59, S86 - S87

Type 2 Diabetes Risk Variants in PAM Reduce Chromogranin A-mediated Insulin Availability and Secretion from Beta Cells

Raimondo A. et al, (2016), DIABETES, 65, A52 - A52

Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.

van de Bunt M. et al, (2016), Islets, 8, 83 - 95

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.

Pal A. et al, (2016), Diabetes, 65, 527 - 533

Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation.

Busche S. et al, (2015), Genome Biol, 16

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.

van de Bunt M. et al, (2015), PLoS Genet, 11

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans

Thomsen SK. et al, (2015), DIABETES, 64, A82 - A83

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

Allum F. et al, (2015), Nat Commun, 6

Genetic studies of body mass index yield new insights for obesity biology.

Locke AE. et al, (2015), Nature, 518, 197 - 206

New genetic loci link adipose and insulin biology to body fat distribution.

Shungin D. et al, (2015), Nature, 518, 187 - 196

Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.

Raimondo A. et al, (2014), Hum Mol Genet, 23, 6432 - 6440

Defining the role of common variation in the genomic and biological architecture of adult human height.

Wood AR. et al, (2014), Nat Genet, 46, 1173 - 1186

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