Publications — Radcliffe Department of Medicine

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Generalised interrelations among mutation rates drive the genomic compliance of Chargaff's second parity rule.

Pflughaupt P. and Sahakyan AB., (2023), Nucleic Acids Res

ROptimus: a parallel general-purpose adaptive optimisation engine.

Johnson NAG. et al, (2023), Bioinformatics

Quantum mechanical electronic and geometric parameters for DNA k-mers as features for machine learning

Masuda K. et al, (2023)

Generalised interrelations among mutation rates drive the genomic compliance of Chargaff’s second parity rule

Pflughaupt P. and Sahakyan AB., (2022)

Optimus: a general purpose adaptive optimisation engine in R

Johnson N. et al, (2022)

Structure-driven effects on genomic DNA damage propensity at G-quadruplex sites

Abdullah AA. et al, (2021)

Thermal and pH stabilities of i-DNA: confronting in vitro experiments with models and in-cell NMR data.

Cheng M. et al, (2021), Angew Chem Int Ed Engl

A Spontaneous Ring Opening Reaction Leads to a Repair‐Resistant T Oxidation Product in Genomic DNA

Sahakyan A. et al, (2019), ChemBioChem

Whole genome experimental maps of DNA G-quadruplexes in multiple species.

Marsico G. et al, (2019), Nucleic Acids Res

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs.

Chan KL. et al, (2018), Chem Commun (Camb), 54, 10878 - 10881

Machine learning model for sequence-driven DNA G-quadruplex formation.

Sahakyan AB. et al, (2017), Sci Rep, 7

G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.

Sahakyan AB. et al, (2017), Nat Struct Mol Biol, 24, 243 - 247

Single genome retrieval of context-dependent variability in mutation rates for human germline.

Sahakyan AB. and Balasubramanian S., (2017), BMC Genomics, 18

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.

Kwok CK. et al, (2016), Nat Methods, 13, 841 - 844

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.

Kwok CK. et al, (2016), Angew Chem Int Ed Engl, 55, 8958 - 8961

Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases.

Sahakyan AB. and Balasubramanian S., (2016), BMC Genomics, 17

Core variability in substitution rates and the basal sequence characteristics of the human genome

Sahakyan A. and Balasubramanian S., (2015)

Selective Chemical Labeling of Natural T Modifications in DNA.

Hardisty RE. et al, (2015), J Am Chem Soc, 137, 9270 - 9272

Revealing the specific solute-solvent interactions via the measurements of the NMR spin-spin coupling constants

Shahkhatuni AA. et al, (2015), Journal of Molecular Structure, 1083, 175 - 178

Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism.

Camilloni C. et al, (2014), Proc Natl Acad Sci U S A, 111, 10203 - 10208

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