DPhil, MRCS (Eng), MA (Cantab)
Academic Clinical Lecturer in Urology
I am a researcher and trainee in urological surgery. My research is based in the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, where I work as part of Professor Rajesh Thakker's group. I studied medicine at Cambridge and Oxford Universities between 1999 and 2005 and since qualification have worked in the Oxford region, entering the Urology training scheme in 2010. I was appointed as a Wellcome Trust clinical training fellow in 2011 and as an NIHR Academic Clinical Lecturer in Urology in 2015.Kidney stone disease is a common problem, affecting up to 20% of men and 10% of women by 70 years of age. Hypercalciuria is linked to an increased risk of forming such stones and my research focuses on trying to understand the tubular process regulating calcium excretion. My approach is to study monogenetic disorders causing either hypercalcaemia or hypercalciuria and identify the molecular pathways resulting in this phenotype.
Genetic variants of calcium and vitamin D metabolism in kidney stone disease
HOWLES S. et al, (2019), Nature Communications
Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.
Howles SA. et al, (2017), JCI Insight, 2
Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.
Gorvin CM. et al, (2017), JCI Insight, 2
Identification of a G-Protein Subunit-α11 Gain-of-Function Mutation, Val340Met, in a Family With Autosomal Dominant Hypocalcemia Type 2 (ADH2).
Piret SE. et al, (2016), J Bone Miner Res, 31, 1207 - 1214
Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders.
Babinsky VN. et al, (2016), J Biol Chem, 291, 10876 - 10885