DPhil, MRCS (Eng), MA (Cantab)
Academic Clinical Lecturer in Urology
I am a researcher and trainee in urological surgery. My research is based in the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, where I work as part of Professor Rajesh Thakker's group. I studied medicine at Cambridge and Oxford Universities between 1999 and 2005 and since qualification have worked in the Oxford region, entering the Urology training scheme in 2010. I was appointed as a Wellcome Trust clinical training fellow in 2011 and as an NIHR Academic Clinical Lecturer in Urology in 2015.Kidney stone disease is a common problem, affecting up to 20% of men and 10% of women by 70 years of age. Hypercalciuria is linked to an increased risk of forming such stones and my research focuses on trying to understand the tubular process regulating calcium excretion. My approach is to study monogenetic disorders causing either hypercalcaemia or hypercalciuria and identify the molecular pathways resulting in this phenotype.
GNA11 variants identified in patients with hypercalcemia or hypocalcemia
Howles S. et al, (2023), Journal of Bone and Mineral Research
Impact of COVID-19 on the management and outcomes of ureteric stones in the UK: a multicentre retrospective study.
Byrne MHV. et al, (2022), BJU Int
Associations of adiposity, kidney stone disease, and serum calcium concentrations; observational and genetic epidemiological studies
Lovegrove C. et al, (2022)
Author Correction: Genetic variants of calcium and vitamin D metabolism in kidney stone disease.
Howles SA. et al, (2022), Nat Commun, 13
Natural history of small asymptomatic kidney and residual stones over a long-term follow-up: systematic review over 25 years.
Lovegrove CE. et al, (2022), BJU Int, 129, 442 - 456