Oxford Neonatal Surgery Course 2016
MA MD FRCS (Paed.Surg) FAAP
Professor of Paediatric Surgery; Director of Oxford Islet Isolation and Islet Transplant Programmes
- Academic Training Programme Director for OUCAGS School of Surgery
- Fellow & Clinical Tutor, St Edmund Hall, University of Oxford
I am Professor of Paediatric Surgery at the University of Oxford, and Director of the Oxford Islet Transplant Programme. I am a Fellow and Clinical Tutor at St Edmund Hall. I qualified in Medicine from the University of Leicester and trained in Paediatric Surgery in Oxford, Melbourne and Great Ormond Street. My particular clinical interests are paediatric and endocrine surgery, and cell transplantation. My research interests include optimising human islet isolation, and understanding normal pancreatic development and islet neogenesis. I was awarded a Hunterian Professorship from the Royal College of Surgeons of England for this research in 1998. I am currently Immediate Past President of the International Pancreas and Islet Association (IPITA) having served as President from 2011-2013. I was awarded an Honorary Fellowship of The American Academy of Paediatrics in February 2010. I currently sit on a number of Research Boards and Editorial Boards. I chair the Nuffield Department of Surgical Sciences Clinical Academic Sub Group.
APSU - The Academic Paediatric Surgery Unit (APSU) undertakes research ranging from basic laboratory science to evidence-based clinical studies. The principal area of research relates to the endocrine pancreas, and in particular the field of pancreatic islet transplantation for juvenile-onset diabetes. The research group comprises clinicians, basic scientists, research fellows, clinical nurse specialists and technicians. Members of the group are currently working towards PhD, MD and MSc degrees.
OXCIT – The Oxford Consortium for Islet Transplantation (OXCIT) is a multi-disciplinary team that aims to achieve insulin independence in patients with diabetes by transplanting pancreatic islets of Langerhans. By simultaneously engaging in detailed basic and clinical research, it is anticipated that the OXCIT team will enable islet transplantation to be applied to children with diabetes in the future.
MiR-184 expression is regulated by AMPK in pancreatic islets.
Martinez-Sanchez A. et al, (2018), FASEB J, 32, 2587 - 2600
A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.
Buenaventura T. et al, (2018), Diabetes, 67, 385 - 399
Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop.
Rickels MR. et al, (2018), Transpl Int, 31, 343 - 352
Hypoxia-Induced Damage in Human Islets Is Reduced With the Use of Mesenchymal Stem Cell-Preconditioned Medium.
Brandhorst D. et al, (2017), Transplant Proc, 49, 2330 - 2332
Effect of Etanercept Concentration on Human Islet Integrity.
Acreman S. et al, (2017), Transplant Proc, 49, 2327 - 2329