Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LE
MA MD FRCS (Paed.Surg) FAAP
Director of Oxford Islet Isolation and Islet Transplant Programmes and Professor of Paediatric Surgery
- Academic Training Programme Director for OUCAGS School of Surgery
- Fellow & Clinical Tutor, St Edmund Hall, University of Oxford
I am Professor of Paediatric Surgery at the University of Oxford, and Director of the Oxford Islet Transplant Programme. I am a Fellow and Clinical Tutor at St Edmund Hall. I qualified in Medicine from the University of Leicester and trained in Paediatric Surgery in Oxford, Melbourne and Great Ormond Street. My particular clinical interests are paediatric and endocrine surgery, and cell transplantation. My research interests include optimising human islet isolation, and understanding normal pancreatic development and islet neogenesis. I was awarded a Hunterian Professorship from the Royal College of Surgeons of England for this research in 1998. I am currently Immediate Past President of the International Pancreas and Islet Association (IPITA) having served as President from 2011-2013. I was awarded an Honorary Fellowship of The American Academy of Paediatrics in February 2010. I currently sit on a number of Research Boards and Editorial Boards. I chair the Nuffield Department of Surgical Sciences Clinical Academic Sub Group.
APSU - The Academic Paediatric Surgery Unit (APSU) undertakes research ranging from basic laboratory science to evidence-based clinical studies. The principal area of research relates to the endocrine pancreas, and in particular the field of pancreatic islet transplantation for juvenile-onset diabetes. The research group comprises clinicians, basic scientists, research fellows, clinical nurse specialists and technicians. Members of the group are currently working towards PhD, MD and MSc degrees.
OXCIT – The Oxford Consortium for Islet Transplantation (OXCIT) is a multi-disciplinary team that aims to achieve insulin independence in patients with diabetes by transplanting pancreatic islets of Langerhans. By simultaneously engaging in detailed basic and clinical research, it is anticipated that the OXCIT team will enable islet transplantation to be applied to children with diabetes in the future.
Beta-cell death and dysfunction drives hyperglycaemia in organ donors.
Shapey IM. et al, (2023), Diabetes Obes Metab
NKCC transport mediates the insulinotropic effects of taurine and other small neutral amino acids.
Turbitt J. et al, (2023), Life Sci, 316
European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy.
Ferrer-Fàbrega J. et al, (2023), Transplant international : official journal of the European Society for Organ Transplantation, 36
Solubilized Pancreatic Extracellular Matrix from Juvenile Pigs Protects Isolated Human Islets from Hypoxia-Induced Damage: A Viable Option for Clinical Islet Transplantation
Brandhorst H. et al, (2023), Journal of Tissue Engineering and Regenerative Medicine, 2023
The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors.
Brandhorst D. et al, (2022), Sci Rep, 12