- Heather Group Research Group
DPhil, MBiochem, MRSB, FHEA
Novo Nordisk Postdoctoral Research Fellow
I am a Novo Nordisk Postdoctoral Researcher Fellow in Dr Lisa Heather's group in the Department of Physiology, Anatomy and Genetics, Oxford. I originally studied Biochemistry at Bath University, before working at Powdermed vaccines in Oxford. After that I came to the Department of Cardiovascular Medicine and the Department of Physiology, Anatomy and Genetics to study for my DPhil.
My research involves examining the metabolism of the failing and diseased heart. The healthy heart derives 60-80% of its energy from the burning of fat, the rest from carbohydrates and ketones. During heart disease this carefully balanced use of fuel can become breakdown.
We are using a host of techniques to understand changes in heart structure, function and metabolism during heart disease. One technique is hyperpolarized magnetic resonance spectroscopy to understand the change in metabolism in these diseased states (done in collaboration with Prof Tyler's group) and example of this can be seen in Figure 1. The focus of my fellowship involves understanding how cardiac metabolism is altered during both diabetes and hypoxia, using cardiac cells.
The 'Goldilocks zone' of fatty acid metabolism; to ensure that the relationship with cardiac function is just right.
Kerr M. et al, (2017), Clin Sci (Lond), 131, 2079 - 2094
Targeting hypoxia-inducible factor 1 (HIF-1) signalling in the Type 2 diabetic heart: dimethyloxaloylglycine (DMOG) improves functional recovery following ischaemia-reperfusion despite no change in glycolysis
Sousa Fialho MDL. et al, (2017)
Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS.
Le Page LM. et al, (2016), NMR Biomed, 29, 1759 - 1767
FATTY ACIDS IMPAIR HIF1 alpha ACTIVATION AND SUPPRESS METABOLIC ADAPTATION TO HYPOXIA IN INSULIN RESISTANCE
Dodd MS. et al, (2016), HEART, 102, A3 - A4
The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.
Slingo M. et al, (2016), Am J Physiol Heart Circ Physiol, 311, H759 - H767
Mitochondria in HL-1 cardiomyocytes