NOVO NORDISK POSTDOCTORAL RESEARCH FELLOW (2014-2017)
- Project: Hypoxic signalling in the type 2 diabetic heart – mechanisms for therapeutic modulation
Michael was awarded a Novo Nordisk Postdoctoral Research Fellowship in 2014, working in Dr Lisa Heather's group in the Department of Physiology, Anatomy & Genetics. The focus of his fellowship involved understanding how cardiac metabolism is altered during both diabetes and hypoxia, using cardiac cells. In particular he wanted to know if diabetes affects induction of the hypoxia signalling pathway, and if so, what component of diabetes inhibits this pathway. Michael also worked on a project with his mentor Dr Bidda Rolin from Novo Nordisk, to understand transcriptional changes in the diabetic heart following short-term global hypoxia.
Following his Novo Nordisk fellowship, in April 2018, Michael was appointed as a Lecturer in Biosciences in the Faculty of Health and Life Sciences at the University of Coventry, UK. Michael will be expanding on his teaching experience from Oxford and will continue to research the relationship between hypoxia and the heart, with an interest in finding out more about oncometabolic regulation in the heart.
Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS.
Timm KN, Apps A, Miller JJ, Ball V, Chong CR, Dodd MS, Tyler DJ (2018), NMR Biomed.
Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes.
Dodd MS, Sousa Fialho MDL, Montes Aparicio CN, Kerr M, Timm KN, Griffin JL, Luiken JJFP, Glatz JFC, Tyler DJ, Heather LC (2018), JACC Basic Transl Sci.
CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Briant LJB, Dodd MS, Chibalina MV, Rorsman NJG, Johnson PRV, Carmeliet P, Rorsman P, Knudsen JG (2018), Cell Rep.
The 'Goldilocks zone' of fatty acid metabolism; to ensure that the relationship with cardiac function is just right
Kerr M, Dodd MS, and Heather LC (2017), Clinical Science.
Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS
Le Page LM., Ball DR., Ball V., Dodd MS., Miller JJ., Heather LC., Tyler DJ (2016), NR Biomed.