Colleges
Joshua (Yifan) Li
MBChB, BMedSci(Hons), DipABRSM, AFHEA
DPhil Candidate
- Specialist Registrar Doctor in Emergency Medicine (locum)
- Lincoln College Non-Stipendiary Lecturer in Clinical Medicine
I am a 2nd year DPhil student in the Toepfer/Watkins Group in the Division of Cardiovascular Medicine, generously supported by the Keith Murray Graduate Scholarship and the Oppenheimer Memorial Trust (OMT) Scholarship.
I grew up in Johannesburg, South Africa and completed my Intercalated MBChB/BMedSci(Hons) degree at the University of Cape Town (UCT) in 2018, graduating with First Class Honours. My Honours project was supervised by Associate Professor Ursula Rohlwink and Professor Tony Figaji of UCT, where I investigated the role of matrix metalloproteinases in paediatric tuberculous meningitis. After graduation, I finished my 2-year medical internship at Worcester Hospital and my year of public service in General Surgery at Mahikeng Provincial Hospital, South Africa. I subsequently worked as an Emergency Medicine Registrar in Dublin for 9 months prior to commencing my DPhil in Lincoln College, Oxford. I hold full registrations in the GMC, IMC and HPCSA.
Now, under the supervision of Associate Professor Christopher Toepfer and Professor Hugh Watkins, I am using tissue engineering to investigate the role of novel gene variants in hypertrophic cardiomyopathy (HCM). My project is a laboratory based functional study guided by the findings from the latest GWAS studies on HCM. I have engineered the novel gene variants using CRISPR/Cas-9 into iPSC-derived cardiomyocytes and I aim to further characterise the model both in 2D and 3D, using engineered heart tissues (EHTs).
Outside the lab, I enjoy fencing, traveling, playing my violin, and reading books while sipping coffee at scenic coffee shops. I am a locum Specialist Registrar at the John Radcliffe Hospital Emergency Department, and I tutor the 5th Year medical students at Lincoln College.
Key publications
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Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.
Journal article
Li YJ. et al, (2020), J Pediatric Infect Dis Soc, 9, 82 - 86
Recent publications
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Ventriculoperitoneal shunt failures at Red Cross War Memorial Children's Hospital.
Journal article
Lazarus JS. et al, (2024), Childs Nerv Syst
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The management and outcomes of hepatocellular carcinoma in sub-Saharan Africa: a systematic review.
Journal article
Sobnach S. et al, (2023), HPB (Oxford)
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Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.
Journal article
Li YJ. et al, (2020), J Pediatric Infect Dis Soc, 9, 82 - 86
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Uneventful survival of a rural child after penetrating cardiac injury by a thorn: a case report.
Journal article
De Decker R. et al, (2019), Eur Heart J Case Rep, 3
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Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review.
Journal article
Rohlwink UK. et al, (2019), Int J Mol Sci, 20