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Felix A Radtke
DPhil Student
My research experience includes studying neutrophil biology in homeostasis and inflammation in humans and mice and novel diagnostical methods for paediatric Lyme disease at Heidelberg University and the Brigham and Women’s Hospital, Harvard Medical School.
After graduating from medical school, I joined the Vyas lab to study haematopoiesis and haematological malignancies. During my time at Oxford, I am focusing my research on the mutational landscape of haematopoietic malignancies and identifying the transcriptomic and epigenetic landscape of patients with acute myeloid leukaemia treated with novel therapeutics. A particular interest is the transcriptomic state and the clonal architecture of TP53 mutations in AML.
By applying and improving novel sequencing technologies, the laboratory aims to understand the events leading to the development of acute myeloid leukaemia and to improve treatment opportunities.
I hold the Oxford – Sir David Weatherall Scholarship from Green Templeton College and am co-funded by the Radcliffe Department of Medicine/Weatherall Institute of Molecular Medicine (WIMM Prize Studentship). I am very grateful to the college and the institute for their support.
Recent publications
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An Overview of Targeted Therapies in Acute Myeloid Leukemia.
Journal article
Turkalj S. et al, (2023), Hemasphere, 7
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Ageing and interferon gamma response drive the phenotype of neutrophils in the inflamed joint.
Journal article
Grieshaber-Bouyer R. et al, (2022), Annals of the rheumatic diseases, 81, 805 - 814
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Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis.
Journal article
Huang FY. et al, (2022), Blood advances, 6, 2081 - 2091
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A Core Inflammation Program Conserved Across Human and Murine Neutrophils
Conference paper
Hackert N. et al, (2022), ARTHRITIS & RHEUMATOLOGY, 74, 3358 - 3359
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Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease.
Journal article
Radtke FA. et al, (2021), Journal of clinical microbiology, 59