Research groups
Colleges
Websites
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BHF
British Heart Foundation
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BHF CRE
British Heart Foundation Centre of Research Excellence
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BSCSC
Burdon Sanderson Cardiac Science Centre
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Wellcome Trust
Wellcome Trust
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Auckland Bioengineering Institute
The University of Auckland
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The Journal of Physiology
The Journal of Physiology
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Media
Videos, Radio & TV
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Public Talks
Seminars & Invited Lectures
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Collaborations
Main Collaborators
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Levick's Introduction to Cardiovascular Physiology
CRC Press
David Paterson
DPhil, DSc
Head of Department
- Professor of Cardiovascular Physiology
- Hon. Director Burdon Sanderson Cardiac Science Centre
David Paterson completed his doctoral studies (D.Phil, New College) in physiological sciences at Oxford having been a graduate of the University of Otago (NZ), and the University of Western Australia. Following a MRC post doc/Junior Research Fellowship (Christ Church) in Oxford, and a BHF lectureship, he was appointed to a University Lecturership in 1994 and made a Fellow of Merton College, Oxford. He received his Doctor of Science (D.Sc) degree from Western Australia in 2005 and was made a Professor of Physiology in 2002. He has been Associate Head then Deputy Head of the Division of Medical Sciences from 2008-16. During this period he Chaired the Divisions Research, Personnel and Education Committees. He is a member of the executive committee of the BHF Centre of Research Excellence at Oxford, and was a member of the national Research Assessment Exercise (RAE 2008) and Research Excellence Framework (REF 2014) panels. From 2011 to 2016 he served as Editor-in-Chief of The Journal of Physiology and is now Consulting Editor for Physiology. He is a Fellow of the Royal Society of Biology and in 2014 was elected an Honorary Fellow of The Royal Society of New Zealand. In 2016 he delivered the Brookhart Award Lecture in Oregon and was appointed Head of Department. He was elected as an inaugural Fellow of The Physiological Society in 2017. In 2018 he delivered the Carl Ludwig Distinguished Lecture for the American Physiological Society at Experimental Biology, and in 2018 elected President-elect of The Physiological Society.
David Paterson leads a research team in the area of cardiac neurobiology. They are interested in how both branches of the cardiac autonomic nervous system communicate at the end organ level and whether oxidative stress plays a role in uncoupling pre-synaptic and post synaptic signalling. The endogenous gas nitric oxide is now thought to be a key intermediary in cardiac inter/intracellular signalling, where it has been shown to regulate several ion channels that control cardiac excitability. His group has developed a method for targeting the enzyme involved in making nitric oxide using a gene transfer approach involving cell specific viral vectors to study the physiology of this messenger in normal and diseased hearts.
Key publications
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Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats.
Journal article
Li D. et al, (2007), Hypertension, 50, 69 - 74
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Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer.
Journal article
Heaton DA. et al, (2006), Hypertension, 48, 443 - 452
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Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained mice.
Journal article
Danson EJF. and Paterson DJ., (2003), J Physiol, 546, 225 - 232
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Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.
Journal article
Mohan RM. et al, (2002), Circ Res, 91, 1089 - 1091
Recent publications
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Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability.
Journal article
Li D. and Paterson DJ., (2019), Semin Cell Dev Biol
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Neurocardiac regulation: From cardiac mechanisms to novel therapeutic approaches.
Journal article
Bardsley EN. and Paterson DJ., (2018), J Physiol
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Transcriptional profiling of stellate ganglia from normotensive and spontaneously hypertensive rat strains.
Journal article
Davis H. et al, (2018), Sci Data, 5
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RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity.
Journal article
Bardsley EN. et al, (2018), Sci Rep, 8
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Neurotransmitter Switching Coupled to β-Adrenergic Signaling in Sympathetic Neurons in Prehypertensive States.
Journal article
Bardsley EN. et al, (2018), Hypertension, 71, 1226 - 1238