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Research by Prof Andrew Wilkie and Prof Anne Goriely, published in PNAS, has identified the origins of some severe disease-causing mutations within the testicles of normal men. Particular mutations in the FGFR2 gene and a few other disease genes enable the mutated spermatogonia to produce not just sperm but extra copies of themselves, reproducing and spreading faster than the surrounding normal spermatogonia. This tumour-like growth means that over time, a greater proportion of sperm being produced carry disease-causing mutations, increasing the risk of fathering a child with a serious condition.
Paul Johnson
OCDEM Principal Investigators
MA MD FRCS (Paed.Surg) FAAP Paul Johnson - Director of Oxford Islet Isolation and Islet Transplant Programmes and Professor of Paediatric Surgery
Peter Rothwell
AMIIC
MD PhD FRCP Peter Rothwell - Founding Director of the Wolfson Centre for the Prevention of Stroke and Dementia and Action Research Professor of Neurology
Naveed Akbar
CVM Principal Investigators
BSc (Hons), MSc, PhD, FHEA Naveed Akbar - Associate Professor of Cardiovascular Science
Stefan Piechnik
CVM OCMR Principal Investigators
DSc, PhD, MScEE, FSCMR Stefan Piechnik - Professor of Biomedical Imaging
Parag Gajendragadkar
CVM Researchers
MA, MB BChir, MPhil (Cantab), DPhil (Oxon), MRCP Parag Gajendragadkar - Senior Clinical Fellow in Electrophysiology
Elizabeth Ormondroyd
CVM Principal Investigators
PhD; MSc Genetic Counselling Elizabeth Ormondroyd - Principal Investigator in RDM; Senior researcher; Genetic counsellor
Reshma Ramracheya
OCDEM Visitors and Affiliates
BSc (Hons), PhD Reshma Ramracheya - Visiting Scientist
Timothy Betts
CVM Principal Investigators
MD, MBChB, FRCP Timothy Betts - Associate Professor of Cardiovascular Medicine
Betty Raman
CVM OCMR Principal Investigators
MBBS DPhil FESC FRACP Betty Raman - Associate Professor of Cardiovascular Medicine
Suzanne Watt
Emeritus Professors NDCLS
B.Sc., B.Sc. (Hons), Ph.D., FRCPath. Suzanne Watt - Emeritus Professor of Haematology