Anne Bridgeman

HSV-1 employs UL56 to antagonize expression and function of cGAMP channels.

Blest HTW. et al, (2024), Cell Rep, 43

Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.

Hertzog J. et al, (2022), EMBO J, 41

Interferon induction held captive in tumor cells.

Bridgeman A. and Rehwinkel J., (2021), Mol Cell, 81, 4109 - 4110

denosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.

Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5

Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.

Chauveau L. et al, (2021), EMBO Rep, 22

Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.

Clapes T. et al, (2021), Nat Cell Biol, 23, 704 - 717

The RNA sensor MDA5 detects SARS-CoV-2 infection.

Sampaio NG. et al, (2021), Sci Rep, 11

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death.

Schilling M. et al, (2020), Cells, 9

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.

Davenne T. et al, (2020), Cell Rep, 31

Deoxyguanosine is a TLR7 agonist.

Davenne T. et al, (2020), Eur J Immunol, 50, 56 - 62

cGAMP loading enhances the immunogenicity of VLP vaccines

Chauveau L. et al, (2020)

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.

Maelfait J. et al, (2017), EMBO J, 36, 2529 - 2543

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Glück S. et al, (2017), Nat Cell Biol, 19, 1061 - 1070

Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.

Mayer A. et al, (2017), Methods Mol Biol, 1656, 143 - 152

Vector delivery-dependant effect of human tissue plasminogen activator signal peptide on vaccine induction of T cells

Hanke T. et al, (2016), Journal of HIV and AIDS

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.

Maelfait J. et al, (2016), Cell Rep, 16, 1492 - 1501

Viruses transfer the antiviral second messenger cGAMP between cells.

Bridgeman A. et al, (2015), Science, 349, 1228 - 1232

Transient IL-10 receptor blockade can enhance CD8(+) T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen.

Clutton G. et al, (2015), Hum Vaccin Immunother, 11, 1030 - 1035

Characterization of T-cell responses to conserved regions of the HIV-1 proteome in BALB/c mice.

Ondondo B. et al, (2014), Clin Vaccine Immunol, 21, 1565 - 1572

Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.

Borthwick N. et al, (2014), Mol Ther, 22, 464 - 475

SAMHD1-dependent retroviral control and escape in mice.

Rehwinkel J. et al, (2013), EMBO J, 32, 2454 - 2462

SAMHD1-dependent retroviral control and escape in mice

Rehwinkel J. et al, (2013), Retrovirology, 10, P70 - P70

Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine.

Knudsen ML. et al, (2012), J Virol, 86, 4082 - 4090

Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques.

Rosario M. et al, (2012), AIDS, 26, 275 - 284

Optimizing HIV-1-specific CD8+ T-cell induction by recombinant BCG in prime-boost regimens with heterologous viral vectors.

Hopkins R. et al, (2011), Eur J Immunol, 41, 3542 - 3552

Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges.

Im E-J. et al, (2011), PLoS Pathog, 7

Contact information

Research groups

Anne Bridgeman

Recent publications

HSV-1 employs UL56 to antagonize expression and function of cGAMP channels.

Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.

Interferon induction held captive in tumor cells.

denosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.

Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.

Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.

The RNA sensor MDA5 detects SARS-CoV-2 infection.

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death.

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.

Deoxyguanosine is a TLR7 agonist.

cGAMP loading enhances the immunogenicity of VLP vaccines

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.

Vector delivery-dependant effect of human tissue plasminogen activator signal peptide on vaccine induction of T cells

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.

Viruses transfer the antiviral second messenger cGAMP between cells.

Transient IL-10 receptor blockade can enhance CD8(+) T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen.

Characterization of T-cell responses to conserved regions of the HIV-1 proteome in BALB/c mice.

Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.

SAMHD1-dependent retroviral control and escape in mice.

SAMHD1-dependent retroviral control and escape in mice

Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine.

Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques.

Optimizing HIV-1-specific CD8+ T-cell induction by recombinant BCG in prime-boost regimens with heterologous viral vectors.

Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges.

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Contact information

Research groups

Anne Bridgeman

Recent publications