PhD, FInstP, CPhys
Herbert Dunhill Professor of Neuroimaging
- FMRIB/WIN Physics Group
My group develops novel physiological MRI methods for the study of healthy and diseased brain.
I am particularly interested in techniques for mapping the macroscopic and microscopic neurovasculature. I collaborate closely with various clinical groups, in particular through the Oxford Acute Vascular Imaging Centre (AVIC), on the development of rapid imaging approaches to aid in the diagnosis and treatment of acute stroke. A second thread of research aims to advance ultra-high field imaging, utilizing our 7-tesla scanner. This research combines novel imaging hardware, including parallel RF transmission, with state-of-the-art acquisition techniques. Finally, I also work with the Dept of Psychiatry on the development of spectroscopic measurement of neurotransmitters.
I am an active member of University College and hold leadership roles in several imaging centres within Oxford (see links to left). In the broader scientific community, I have been active in the International Society for Magnetic Resonance in Medicine in a range of capacities, and am the Editor-in-Chief of the Society journal Magnetic Resonance in Medicine from January 2020.
Volume-localized measurement of oxygen extraction fraction in the brain using MRI.
O'Brien C. et al, (2019), Magnetic resonance in medicine
Quantifying T<sub>2</sub> relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients.
Damion R. et al, (2019), Phys Med Biol
A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy.
Shen X. et al, (2019), Metabolites, 9
Visualizing artery-specific blood flow patterns above the circle of Willis with vessel-encoded arterial spin labeling.
Okell TW. et al, (2018), Magn Reson Med
Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla.
Steel A. et al, (2018), Sci Rep, 8