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BM DPhil FRCA
Senior Clinical Research Fellow
- Consultant Anaesthetist and Associate Professor
FMRI of respiratory control
Disorders of respiratory control are implicated in a wide spectrum of disease including: chronic obstructive airways disease, asthma, neurodegenerative diseases, sleep apnoea and sudden infant death syndrome. In particular, chronic obstructive airways disease causes distressing shortness of breath, and is one of the major debilitating diseases in the world. Drugs used for pain relief, such as morphine, have potentially fatal side effects due to their effects upon respiratory centres in the brain. My research centres upon investigating mechanisms of respiratory control, and the processes underlying breathlessness, using non-invasive magnetic resonance imaging techniques.
Imaging brain perfusion changes following aneurysmal subarachnoid haemorrhage
Delayed cerebral ischaemia is a major cause of morbidity and mortality following subarachnoid haemorrhage. Successful targeted treatment requires an accurate, non-invasive, and reproducible measure of cerebral perfusion. Current techniques are limited in their clinical application as they only image larger arteries and require the use of contrast agents and/or ionising radiation. We are trialing novel magnetic resonance imaging techniques that do not require exogenous contrast agents that demonstrate quantitative measures of cerebral perfusion at the tissue level. This would potentially facilitate the early and targeted use of vasospasm therapies and so reduce long-term morbidity and mortality.
Breathlessness and the brain: The role of expectation
MARLOW L. et al, (2019), Current Opinion in Supportive and Palliative Care
Opioids for breathlessness: Psychological and neural factors influencing response variability.
Abdallah SJ. et al, (2019), Eur Respir J
The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing.
Faull OK. et al, (2019), Neurosci Biobehav Rev, 98, 135 - 144
Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia.
Rowland MJ. et al, (2019), J Cereb Blood Flow Metab, 39, 285 - 301
Modeling of dynamic cerebrovascular reactivity to spontaneous and externally induced CO2 fluctuations in the human brain using BOLD-fMRI.
Prokopiou PC. et al, (2019), Neuroimage, 186, 533 - 548