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CARDIOVASCULAR DISEASE AND PREGNANCY RESEARCH COLLABORATIVE (CDPRC)

About us

The Oxford Cardiovascular Disease and Pregnancy Research Collaborative (CDPRC) was established in 2021. Our collaboration brings together specialists in cellular work, imaging, clinical trials and engineering across cardiovascular medicine, maternal & women’s health, fetal medicine, and global population health. Our aim is to facilitate innovative, cross-disciplinary thinking about the reasons cardiovascular diseases that emerge during pregnancy are linked with those that occur later in life and use these insights to identify new management approaches that benefit patients with cardiovascular diseases during pregnancy and throughout their life course.

Research groups involved in the collaboration make use of imaging and laboratory studies to identify early cardiac and vascular changes during the life of women and their children, particularly following a hypertensive pregnancy. Further work includes addressing the pathogenesis of women’s cardiovascular health disorders through genomic, molecular and environmental epidemiology research methods and focussing on improving the experience of patients by utilising big data to develop digital health interventions.

RESEARCH THEMES

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Cellular and Basic Science

We want to understand how changes in the systemic circulation including blood components, hormonal signalling, extracellular vesicles, endothelial cells and placenta are related to the initiation and development of cardiovascular diseases.

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Observational Imaging Studies

We use multimodality imaging (including echocardiography, magnetic resonance imaging, vascular ultrasound and microvascular imaging) to identify the unique differences in cardiac, vascular, and cerebrovascular systems that mothers and their offspring have after pregnancy complications such as hypertensive pregnancy and preterm birth.

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Clinical Trials

We conduct clinical trials to study the impact of cardiovascular disease in pregnancy and to evaluate the effects of interventions on health outcomes for both mother and child. 

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Machine Learning

We integrate large databases of electronic health records, observational imaging studies, clinical trials, meta-analyses and digital technologies to better understand the determinants and consequences of pregnancy complications and long-term risk of cardiovascular disease, and how to improve quality of care and health outcomes.

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Epidemiology and Global Health

We apply epidemiological and quantitative research methods to carefully developed and design studies to understand the global burden and major determinants of cardiovascular diseases related to pregnancy complications.

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Applied Research in Public Health 

We use a variety of methodologies such as individual-patient meta-analysis, large-scale decentralised clinical trials, and digital health technologies (including using artificial intelligence) to understand cardiovascular risk management during and post pregnancy.

Funders

British Heart Foundation logoNational Institute for Health Research LogoUKRI logo

COLLABORATING DEPARTMENTS AND UNITS

Nuffield Department of Women's and Reproductive HealthRDM LogoNuffield Department of Primary Care Health SciencesNuffield Department of Population HealthOxford University Department of Computer Science

MRC programme grant

A 5 year programme starting in 2022 to generate insights into how disease affects the heart, brain and vasculature, in women and children following a hypertensive pregnancy. Find out more.