Contact information

Email
james.grist@cardiov.ox.ac.uk

Colleges

Brasenose College

Collaborators

Andrew Lewis

Principal Investigator
Damian Tyler

Professor of Physiological Metabolism
Andrew Armitage

Senior Postdoctoral Scientist
Daniel Atkinson

DPhil Student
Suryava Bhattacharya

Postdoctoral MR Physicist
Alice Conner

DPhil Student
Hal Drakesmith

Professor of Iron Biology
Jordan McGing

Postdoctoral Research Assistant
Jack Miller

Novo Nordisk Postdoctoral Research Fellow (2017-2021)
Rebecca Mills

Lead MRI Radiographer
Stefan Neubauer

Professor of Cardiovascular Medicine
Michael Pavlides

Head of liver imaging at OCMR
Jenny Rayner

Senior Clinical Research Fellow
Oliver Rider

Professor of Cardiovascular Medicine
Anna Rose
Ladislav Valkovic

Associate Professor of Metabolic Imaging

James Grist

BSc PhD MInstP FIPEM

Principal Investigator

Clinical neuroimaging

WHO AM I AND WHAT DO WE DO

I'm a physicist working in Magnetic Resonance Imaging. I've got a background in Medical Physics, a PhD in neuroradiology, and a keen interest in being able to image biology!

Our research group works on improving and applying clinical neuro imaging, in stroke, patients eligible for deep brain stimulation, multiple sclerosis, and paediatric neurooncology.

Our group is open to applications for MSc and PhD students as well as work experience!

DPhil Projects Available

2026 Grist Group: A Unified Deep Learning Framework for Multimodal Imaging of the Healthy Human Lung — Radcliffe Department of Medicine

Research groups

Key publications

lgebraic methods and computational strategies for pseudoinverse-based MR image reconstruction (Pinv-Recon).

Yeung K. et al, (2025), Sci Rep, 15

ssessment of a diffusion phantom for quality assurance in brain microstructure diffusion MRI studies.

Ricchi M. et al, (2025), Sci Rep, 15

Consensus Recommendations for Hyperpolarized [1-13C]pyruvate MRI Multi-center Human Studies.

Punwani S. et al, (2025), ArXiv

"The MRI education course" - A free resource for the community to provide MRI education, across the Europe and Iran, established during the COVID-19 pandemic.

Bortolotti L. et al, (2023), Magn Reson Med, 89, 497 - 498

13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Miller JJ. et al, (2018), Sci Rep, 8

Recent publications

Editorial for Quantitative Real-Time MRI for the Assessment of Gastric Motility.

Grist JT., (2026), Journal of magnetic resonance imaging : JMRI

Protocol of the RADIO-STAR trial: a phase 1 safety and dose finding study of hypofractionated radiotherapy to the stellate ganglia for the treatment of ventricular arrhythmia.

Bussmann BM. et al, (2026), BMJ Open, 16

pilot study on protocol consistency and graph metric reproducibility in microstructure-weighted connectomes.

Cavallo M. et al, (2026), Sci Rep

Editorial for "The Sense of Smell (SoS) Atlas: Its Creation and First Application to Investigate COVID-19 Related Anosmia With a Comprehensive Quantitative MRI Protocol".

Dmytriw A. et al, (2026), J Magn Reson Imaging, 63, 594 - 595

Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation

Grist JT. et al, (2026)

The effects of elevated serum lactate on measures of apparent cerebral metabolism and perfusion in the anesthetised rodent brain

Radford-Smith D. et al, (2025)

IMPROVE-DiCE, a 2-Part, Open-Label, Phase 2a Trial Evaluating the Safety and Effectiveness of Ninerafaxstat in Patients With Cardiometabolic Syndromes.

Hundertmark MJ. et al, (2025), Circulation

Predictive modeling of long-term improvement in occlusion outcomes following Woven EndoBridge treatment of cerebral aneurysms: A machine learning approach.

Karandish A. et al, (2025), Interv Neuroradiol

lgebraic methods and computational strategies for pseudoinverse-based MR image reconstruction (Pinv-Recon).

Yeung K. et al, (2025), Sci Rep, 15

Consensus recommendations for hyperpolarized [1-13C]pyruvate MRI multi-center human studies.

Punwani S. et al, (2025), Magn Reson Med, 94, 1386 - 1400

Novel Applications of Generalized MR Image Reconstruction via Direct Pseudoinversion of the Encoding Matrix (Pinv-Recon)

Yeung K. et al, (2025), ISMRM Annual Meeting

Computational Feasibility of MR Image Reconstruction via Explicit Construction and Inversion of the Encoding Matrix

Yeung K. et al, (2025), ISMRM Annual Meeting

ccurate Paediatric Brain Tumour Classification Through Improved Quantitative Analysis of 1H MR Imaging and Spectroscopy.

Zhao T. et al, (2025), NMR Biomed, 38

ssessment of a diffusion phantom for quality assurance in brain microstructure diffusion MRI studies.

Ricchi M. et al, (2025), Sci Rep, 15

ssessment of a diffusion phantom for quality assurance in brain microstructure diffusion MRI studies

Ricchi M. et al, (2025)

Consensus Recommendations for Hyperpolarized [1-13C]pyruvate MRI Multi-center Human Studies.

Punwani S. et al, (2025), ArXiv

Evaluation of an integrated variable flip angle protocol to estimate coil B1 for hyperpolarized MRI.

Yeung K. et al, (2025), Magn Reson Med, 93, 1615 - 1628

Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI.

Ricchi M. et al, (2025), Eur Radiol Exp, 9

Editorial for "The Diagnostic Value of Conventional MRI Combined With Diffusion-Weighted Imaging in Microprolactinomas".

Grist JT., (2025), J Magn Reson Imaging, 61, 1168 - 1169

Integrating multiparametric MRI with spatial transcriptomics to identify "Radio-Spatial Genomic" features of prostate cancer using artificial intelligence

Anbarasan T. et al, (2025), CANCER RESEARCH, 85

Clinical Applications of Hyperpolarised Xenon-129 MRI

Ng KL. et al, (2024), European Medical Journal, 48 - 61

Enabling SENSE Accelerated 2D CSI For Hyperpolarized Carbon-13 Imaging

Shinozaki A. et al, (2024), ISMRM Annual Meeting

ssessment of the repeatability and stability of NODDI diffusion modelling using phantom and in vivo acquisitions.

Ricchi M. et al, (2024), ISMRM Annual Meeting

Increased Cerebral Lactate-to-Pyruvate Ratio in Primary Progressive Multiple Sclerosis using Hyperpolarized Pyruvate MRI.

McGing J. et al, (2024), ISMRM Annual Meeting

Integrated B0 and B1 mapping and image correction for hyperpolarized Carbon-13 metabolic imaging in the human brain

Yeung K. et al, (2024), ISMRM Annual Meeting

Fostering Confidence: Evaluating the Reproducibility and Reliability of Bingham-NODDI Model Measures on Different 3.0 T MRI Scanners

Sgambelluri N. et al, (2024), ISMRM Annual Meeting

IRON-HEART: Cardiac and skeletal muscle energetics in chronic heart failure and iron deficiency

Birkhoelzer S. et al, (2024), ISMRM Annual Meeting

Editorial for "Cerebral Blood Flow Patterns in Patients With Low-Flow Carotid Artery Stenosis, a 4D-PCMRI Assessment".

Healicon R. et al, (2024), J Magn Reson Imaging, 60, 1530 - 1531

Enabling SENSE accelerated 2D CSI for hyperpolarized carbon-13 imaging.

Shinozaki A. et al, (2024), Sci Rep, 14

Pre-Prepared, Low-Cost, Mass-Produced Phantom Regulated by the Food Standards Agency for Assessing Imaging Characteristics within MRI

Axford A. et al, (2024), ISMRM Annual Meeting

Mapping transmit and receive B1 using variable flip angle acquisition on a person-by-person basis for hyperpolarized Carbon-13 and Xenon-129 MRI

Yeung K. et al, (2024), ISMRM Annual Meeting

Factors influencing human brain metabolite SNR in studies with hyperpolarized [1-13C]pyruvate

McLean M. et al, (2024), ISMRM Annual Meeting

Multi-Nuclear MRI/MRS Study Exploring the Impact of a Novel Cardiac Mitotrope in the Treatment of Diabetic Cardiomyopathy

Tyler D. et al, (2024), ISMRM Annual Meeting

The effect of elevated serum lactate on measures of apparent cerebral metabolism and perfusion in the anesthetised rodent brain.

McGing J. et al, (2024), ISMRM Annual Meeting

Editorial for "Oscillating Gradient Diffusion-Weighted MRI for Risk Stratification of Uterine Endometrial Cancer".

Yeung K. et al, (2024), J Magn Reson Imaging, 60, 78 - 79

Multimodal Deformable Image Registration for Long-COVID Analysis Based on Progressive Alignment and Multi-perspective Loss

Li J. et al, (2024)

Noise suppression of proton magnetic resonance spectroscopy improves paediatric brain tumour classification.

Zhao T. et al, (2024), NMR Biomed, 37

Review of Hyperpolarized Pulmonary Functional 129 Xe MR for Long-COVID.

Wild JM. et al, (2024), J Magn Reson Imaging, 59, 1120 - 1134

Review of Hyperpolarized Pulmonary Functional 129Xe MR for Long‐COVID

Wild JM. et al, (2024), Journal of Magnetic Resonance Imaging, 59

Functional Impairment in Small Airways Associated With the Breathlessness Symptoms in Long-Coronavirus Disease.

Kim M. et al, (2024), J Thorac Imaging, 39, 79 - 85

Editorial for "T2 Mapping of Patellar Cartilage After a Single First-Time Episode of Traumatic Lateral Patellar Dislocation".

McGing J. et al, (2024), J Magn Reson Imaging, 59, 877 - 878

Modulating Cardiac Energetics in Cardio-Metabolic Syndromes: A mechanistic, hyperpolarized MR Trial of Ninerafaxstat Treatment

Hundertmark M. et al, (2024)

Multimodal Deformable Image Registration for Long-COVID Analysis Based on Progressive Alignment and Multi-perspective Loss

Li J. et al, (2024), 14860 LNCS, 216 - 226

The EXPLAIN (Hyperpolarised Xenon Magnetic Resonance Pulmonary Imaging in Patients With Long-COVID) Study: The Primary Outcome

Ng K. et al, (2024), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 209

Contrast enhanced MRI does not detect differences in pulmonary perfusion between patients with long COVID and controls

Saunders L. et al, (2024), EUROPEAN RESPIRATORY JOURNAL, 64

HypErpolarised Xenon Magnetic Resonance PuLmonary Imaging in PAtIeNts with LongCOVID (EXPLAIN): Lung diffusion findings

Fraser E. et al, (2024), EUROPEAN RESPIRATORY JOURNAL, 64

Multimodal Deformable Image Registration for Long-COVID Analysis Based on Progressive Alignment and Multi-perspective Loss.

Li J. et al, (2024), MIUA (2), 14860, 216 - 226

S19 Gas exchange imaging using dissolved-phase 129Xe MRI in post COVID cohorts

Saunders LC. et al, (2023), ‘Shake it off’ – Recovery from COVID-19, A18 - A19

Erratum for: Lung Abnormalities Detected with Hyperpolarized 129Xe MRI in Patients with Long COVID.

Grist JT. et al, (2023), Radiology, 309

Directly Bound Deuterons Increase X-Nuclei Hyperpolarization using Dynamic Nuclear Polarization.

Rooney CHE. et al, (2023), Chemphyschem, 24

Longitudinal Lung Function Assessment of Patients Hospitalized With COVID-19 Using 1H and 129Xe Lung MRI.

Saunders LC. et al, (2023), Chest, 164, 700 - 716

Hyperpolarized Carbon 13 MRI: Clinical Applications and Future Directions in Oncology.

Deen SS. et al, (2023), Radiol Imaging Cancer, 5

Parallel imaging of hyperpolarized 13C MRI using 23Na sensitivity profiles

Olin R. et al, (2023), ISMRM Annual Meeting

multivariate blood metabolite algorithm stably predicts risk and resilience to major depressive disorder in the general population.

Radford-Smith DE. et al, (2023), EBioMedicine, 93

Editorial for "Age-Dependent Changes in Knee Cartilage T1 , T2 , and T1p Simultaneously Measured Using MRI Fingerprinting".

Axford A. and Grist JT., (2023), J Magn Reson Imaging, 57, 1813 - 1814

pplying machine learning classifiers to automate quality assessment of paediatric dynamic susceptibility contrast (DSC-) MRI data.

Powell SJ. et al, (2023), Br J Radiol, 96

Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data.

Kapadia A. et al, (2023), J Clin Neurol, 19, 131 - 137

"The MRI education course" - A free resource for the community to provide MRI education, across the Europe and Iran, established during the COVID-19 pandemic.

Bortolotti L. et al, (2023), Magn Reson Med, 89, 497 - 498

Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging.

Grist JT. et al, (2023), Sci Rep, 13

ge, sex and lung volume dependence of 129Xe MRI gas exchange metrics

Collier G. et al, (2023), EUROPEAN RESPIRATORY JOURNAL, 62

Impaired xenon gas transfer observed two years after COVID-19 hospitalisation in patients with signs of interstitial lung disease

Saunders L. et al, (2023), EUROPEAN RESPIRATORY JOURNAL, 62

Fractal dimension analysis to assess ventilation heterogeneity associated with LongCOVID breathlessness

Hwang J. et al, (2023), EUROPEAN RESPIRATORY JOURNAL, 62

Blood metabolites stably predict resilience in individuals at risk of major depressive disorder

Radford-Smith D. et al, (2023), BRAIN BEHAVIOR AND IMMUNITY, 114, 58 - 58

Unexplained lung function differences in dyspnoeic non-hospitalised Long-COVID (NHLC) patients and asymptomatic fully recovered COVID-19 controls - the EXPLAIN study

Ng K. et al, (2023), EUROPEAN RESPIRATORY JOURNAL, 62

Lung Abnormalities Detected with Hyperpolarized 129Xe MRI in Patients with Long COVID.

Grist JT. et al, (2022), Radiology, 305, 709 - 717

ge related increase in internal jugular vein size parallels temporal development of periventricular white matter hyperintensities.

Alqabbani A. et al, (2022), Clin Anat, 35, 974 - 978

ssessing the effect of anesthetic gas mixtures on hyperpolarized 13 C pyruvate metabolism in the rat brain.

Healicon R. et al, (2022), Magn Reson Med, 88, 1324 - 1332

Lactate saturation limits bicarbonate detection in hyperpolarized 13 C-pyruvate MRI of the brain.

Bøgh N. et al, (2022), Magn Reson Med, 88, 1170 - 1179

Predicting Survival in Patients with Brain Tumors: Current State-of-the-Art of AI Methods Applied to MRI.

di Noia C. et al, (2022), Diagnostics (Basel), 12

RF coil design for accurate parallel imaging on 13 C MRSI using 23 Na sensitivity profiles.

Sanchez-Heredia JD. et al, (2022), Magn Reson Med, 88, 1391 - 1405

Brain Tumor Diagnosis Using Machine Learning, Convolutional Neural Networks, Capsule Neural Networks and Vision Transformers, Applied to MRI: A Survey.

Akinyelu AA. et al, (2022), J Imaging, 8

Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-13C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study.

Zaccagna F. et al, (2022), Radiol Imaging Cancer, 4

Metabolite selection for machine learning in childhood brain tumour classification.

Zhao D. et al, (2022), NMR Biomed, 35

Divergent trajectories of antiviral memory after SARS-CoV-2 infection.

Tomic A. et al, (2022), Nat Commun, 13

Complete Genome Sequence Data for the Grapevine Crown Gall-Inhibiting Bacteria Allorhizobium vitis F2/5.

Xi H. et al, (2022), Mol Plant Microbe Interact, 35, 174 - 176

Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study.

Ursprung S. et al, (2022), Cancers (Basel), 14

Metabolic clearance rate modeling: A translational approach to quantifying cerebral metabolism using hyperpolarized [1-13C]pyruvate

Grist J. et al, (2022)

The Investigation of Pulmonary Abnormalities using Hyperpolarised Xenon Magnetic Resonance Imaging in Patients with Long-COVID

Grist J. et al, (2022)

Longitudinal lung function assessment of patients hospitalised with COVID-19 using1H and129Xe lung MRI

Saunders L. et al, (2022)

phase 2a trial investigating ninerafaxstat - a novel cardiac mitotrope for the treatment of diabetic cardiomyopathy (IMPROVE-DiCE)

Hundertmark M. et al, (2022), EUROPEAN HEART JOURNAL, 43, 246 - 246

Frequency drift in MR spectroscopy at 3T.

Hui SCN. et al, (2021), Neuroimage, 241

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

Jarvis LB. et al, (2021), Commun Biol, 4

Hyperpolarized 129Xe MRI Abnormalities in Dyspneic Patients 3 Months after COVID-19 Pneumonia: Preliminary Results.

Grist JT. et al, (2021), Radiology, 301, E353 - E360

Editorial for "Value of Dynamic Contrast Enhanced (DCE) MRI in Predicting Response to Foam Sclerotherapy of Venous Malformations".

Grist JT. and Zaccagna F., (2021), J Magn Reson Imaging, 54, 1117 - 1118

ificial intelligence for early prediction of treatment response in glioblastoma

Patel M. et al, (2021), Neuro-oncology, 23, iv1 - iv1

Combining multi-site magnetic resonance imaging with machine learning predicts survival in pediatric brain tumors.

Grist JT. et al, (2021), Sci Rep, 11

Imaging and treatment of brain tumors through molecular targeting: Recent clinical advances.

Zaccagna F. et al, (2021), Eur J Radiol, 142

Machine learning-based radiomic evaluation of treatment response prediction in glioblastoma.

Patel M. et al, (2021), Clin Radiol, 76, 628.e17 - 628.e27

Investigating the relationship between diffusion kurtosis tensor imaging (DKTI) and histology within the normal human brain.

Maiter A. et al, (2021), Sci Rep, 11

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses.

Ogbe A. et al, (2021), Nat Commun, 12

Hyperpolarized 13 C magnetic resonance imaging for noninvasive assessment of tissue inflammation.

Anderson S. et al, (2021), NMR Biomed, 34

Sodium (23Na) MRI of the Kidney: Experimental Protocol.

Grist JT. et al, (2021), 2216, 473 - 480

nalysis Protocol for Renal Sodium (23Na) MR Imaging.

Grist JT. et al, (2021), 2216, 689 - 696

Sodium (23Na) MRI of the Kidney: Basic Concept.

Grist JT. et al, (2021), 2216, 257 - 266

Divergent trajectories of antiviral memory after SARS-Cov-2 infection

Tomic* A. et al, (2021)

RTIFICIAL INTELLIGENCE FOR EARLY PREDICTION OF TREATMENT RESPONSE IN GLIOBLASTOMA

Patel M. et al, (2021), NEURO-ONCOLOGY, 23, 1 - 1

Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study.

Grist JT. et al, (2020), Kidney Int, 98, 1174 - 1178

Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances.

Grist JT. et al, (2020), Magn Reson Med, 84, 1817 - 1827

Detection of acute kidney injury with hyperpolarized [13 C, 15 N]Urea and multiexponential relaxation modeling.

Grist JT. et al, (2020), Magn Reson Med, 84, 943 - 949

Hyperpolarized 13C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer.

Woitek R. et al, (2020), Radiol Imaging Cancer, 2

Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease.

Grist JT. et al, (2020), J Cereb Blood Flow Metab, 40, 1137 - 1147

Combining multi-site Magnetic Resonance Imaging with machine learning predicts survival in paediatric brain tumours

Grist JT. et al, (2020)

Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI.

Rider OJ. et al, (2020), Circ Res, 126, 725 - 736

Imaging breast cancer using hyperpolarized carbon-13 MRI.

Gallagher FA. et al, (2020), Proc Natl Acad Sci U S A, 117, 2092 - 2098

Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: A multi-site study.

Grist JT. et al, (2020), Neuroimage Clin, 25

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

Ogbe A. et al, (2020)

Therapeutically expanded human regulatory T-cells are super- suppressive due to HIF1A induced expression of CD73.

Jarvis L. et al, (2020)

PREDICTING SURVIVAL FROM PERFUSION AND DIFFUSION MRI BY MACHINE LEARNING

Grist JT. et al, (2020), NEURO-ONCOLOGY, 22, 356 - 356

High field MR and neurological disorders

Grist JT. et al, (2020)

Sodium homeostasis in the tumour microenvironment.

Leslie TK. et al, (2019), Biochim Biophys Acta Rev Cancer, 1872

The detection of acute kidney injury with hyperpolarized 13C Urea and multi-exponential fitting

Grist JT. et al, (2019)

Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: a multi-site study

Grist JT. et al, (2019)

Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.

Zaccagna F. et al, (2019), Eur Radiol, 29, 5559 - 5566

Utilising functional imaging to predict survival in paediatric brain tumours.

Grist J. et al, (2019), Neuro-oncology, 21, iv5 - iv5

Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

Grist JT. et al, (2019), Neuroimage, 189, 171 - 179

Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.

Deen SS. et al, (2019), Eur J Radiol Open, 6, 156 - 162

UTILISING FUNCTIONAL IMAGING TO PREDICT SURVIVAL IN PAEDIATRIC BRAIN TUMOURS.

Grist J. et al, (2019), NEURO-ONCOLOGY, 21, 5 - 5

13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Miller JJ. et al, (2018), Sci Rep, 8

Role of PROPELLER-DWI of the prostate in reducing distortion and artefact from total hip replacement metalwork.

Czarniecki M. et al, (2018), Eur J Radiol, 102, 213 - 219

Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: a clinical tool for studying tumour metabolism.

Zaccagna F. et al, (2018), Br J Radiol, 91

Imaging intralesional heterogeneity of sodium concentration in multiple sclerosis: Initial evidence from 23Na-MRI.

Grist JT. et al, (2018), J Neurol Sci, 387, 111 - 114

Justify your alpha

Lakens D. et al, (2018), Nature Human Behaviour, 2, 168 - 171

Extracellular Lactate: A Novel Measure of T Cell Proliferation.

Grist JT. et al, (2018), J Immunol, 200, 1220 - 1226

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