Spatial Cardiology Lab
- Division of Cardiovascular Medicine
- Oxford Centre for Clinical Magnetic Resonance Research
From molecules to medicines for failing hearts.
Led by Dr Andrew Lewis, we are an interdisciplinary team harnessing the power of imaging across spatial scales to understand and treat human heart disease.
Our research spans from molecular events within individual cells to comprehensive whole-heart analysis, offering a unique perspective on how cardiovascular disease develops and progresses. By integrating human cells, tissue samples, and non-invasive imaging of patients and trial participants, we bridge basic science and clinical application thus maximising the translational potential and impact of everything we do.
What we do
We develop and apply advanced imaging techniques across spatial scales to uncover cardiovascular disease mechanisms, identify new therapeutic targets, and detect treatment effects earlier in experimental medicine trials in cafrdiovascular disease. Our current work focuses on metabolic and immunological pathways in heart failure, using state-of-the-art spatial profiling to map disease processes with unprecedented detail. We believe that understanding how these pathways interact, from subcellular compartments to organ-level function, is key to developing more effective translatable treatments.
Our approach
We take a human-first experimental medicine approach, combining single-cell and spatial -omics with deep cardiovascular phenotyping. This allows us to pursue novel target discovery while developing imaging biomarkers that can de-risk and accelerate early-phase clinical trials.
Join us
We collaborate with partners across Oxford, the UK, and internationally, and we're always looking for talented people who share our curiosity. Whether your background is in imaging, metabolism, immunology, computational biology, or clinical research, or something else we'd love to hear from you about your ideas.
Our team
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Andrew Lewis
Principal Investigator
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Hongyan Tao
DPhil Student
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Pok-Tin Tang
British Heart Foundation Clinical Research Fellow and DPhil Student
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Roshan Xavier
DPhil Student
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Josephine Watkins
DPhil Student
Collaborators
- Dr Jana Grune (Charite, Berlin)
- Prof Chris Toepfer
- Dr Filipa Simoes (IDRM ,University of Oxford)
- Prof Naveed Akhbar
- Dr Noor Momin (University of Pennsylvania)
- Dr Maarten Huslmans (Massachusetts General Hospital)
- Prof Matthias Nahrendorf (Massachusetts General Hospital)
- Prof Oliver Rider
- Dr Jack Miller (Aarhus University)