Investigative Medicine Division
We aim to rapidly translate innovative science into patient benefit across a range of disease areas. From molecular biology and target discovery, through to interventional medicine and informing policy, we bring together researchers in a diverse range of specialties including acute stroke, dementia and immunology.
Head of Division
Latest publications
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Author Correction: Spatial fibroblast niches define Crohn's fistulae.
Journal article
McGregor C. et al, (2025), Nature
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Spatial fibroblast niches define Crohn's fistulae.
Journal article
McGregor C. et al, (2025), Nature
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Subcutaneous administration of the malaria R21/Matrix M vaccine and immune complex formation with anti-circumsporozoite protein mAb 2A10 elicit protective efficacy in mice
Journal article
Mukhopadhyay E. et al, (2025), Frontiers in Immunology, 16
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Anatomic Relationship Between the Greater Occipital Nerve and the Axis: Is It Possible to Safely Insert a Percutaneous C2 Screw Without Causing Occipital Neuralgia?
Journal article
Khadanovich A. et al, (2025), Operative Neurosurgery
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Development and validation of peripheral blood DNA methylation signatures to predict response to biological therapy in adults with Crohn's disease (EPIC-CD): an epigenome-wide association study.
Journal article
Joustra VW. et al, (2025), Lancet Gastroenterol Hepatol
Specific research groups include:
The Buchan Group's Laboratory of Cerebral Ischemia is a pre-clinical research group aiming to uncover mechanisms of cell death in stroke, and develop novel strategies to reduce this. Group members have also developed in-vitro models for neurological diseases.
The MRC Translational Immune Discovery Unit (TIDU) aims to uncover the molecular pathways driving immune-mediated diseases – researchers in the unit develop and harness new technologies to map the causes and molecular drivers of a series of inflammatory disorders in order to develop better ways to treat them.
Professor Alison Simmons is the Head of Investigative Medicine.
Researchers have major collaborations with the MRC, the Wellcome Trust, CRUK and the NIHR, as well as cross-departmental collaborations such as Human Iron Research at Oxford (HIRO).
Latest news
Battle in the Gut at IF Oxford 2025
25 November 2025
In October 2025, researchers from the MRC Translational Immune Discovery Unit led activities on researching gut bacteria at Oxford Science + Ideas Festival.
Professor James Chalmers to join the Radcliffe Department of Medicine
17 November 2025
We are delighted to announce that Professor James Chalmers has been recruited to the statutory Rhodes Professorship of Experimental Therapeutics and Clinical Pharmacology at the University of Oxford. Professor Chalmers is currently GSK/Asthma and Lung UK Professor of Respiratory Medicine at the University of Dundee.
Award to support RDM research in dementia after stroke
3 February 2025
Race Against Dementia, in partnership with Alzheimer’s Research UK have awarded just over £340k to support research into understanding why some people develop dementia after suffering a stroke.