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Research by Prof Andrew Wilkie and Prof Anne Goriely, published in PNAS, has identified the origins of some severe disease-causing mutations within the testicles of normal men. Particular mutations in the FGFR2 gene and a few other disease genes enable the mutated spermatogonia to produce not just sperm but extra copies of themselves, reproducing and spreading faster than the surrounding normal spermatogonia. This tumour-like growth means that over time, a greater proportion of sperm being produced carry disease-causing mutations, increasing the risk of fathering a child with a serious condition.
Masliza Mahmod
CVM OCMR Principal Investigators
MBChB MMed MRCP DPhil Masliza Mahmod - Visiting Professor of Cardiovascular Medicine
Naveed Akbar
CVM Principal Investigators
BSc (Hons), MSc, PhD, FHEA Naveed Akbar - ASSOCIATE PROFESSOR OF CARDIOVASCULAR SCIENCE
Betty Raman
CVM OCMR Principal Investigators
MBBS DPhil FESC FRACP Betty Raman - Associate Professor of Cardiovascular Medicine
Timothy Betts
CVM Principal Investigators
MD, MBChB, FRCP Timothy Betts - Associate Professor of Cardiovascular Medicine
Elizabeth Ormondroyd
CVM Principal Investigators
PhD; MSc Genetic Counselling Elizabeth Ormondroyd - Principal Investigator in RDM; Senior researcher; Genetic counsellor
Stefan Piechnik
CVM OCMR Principal Investigators
DSc, PhD, MScEE, FSCMR Stefan Piechnik - Professor of Biomedical Imaging
Parag Gajendragadkar
CVM Researchers
MA, MB BChir, MPhil (Cantab), DPhil (Oxon), MRCP Parag Gajendragadkar - Senior Clinical Fellow in Electrophysiology
Svetlana Reilly
CVM Principal Investigators
MD DPhil (Oxon) Svetlana Reilly - Associate Professor of Cardiovascular Science and British Heart Foundation Senior Research Fellow
Yiangos Psaras
CVM Students
BSc (Hons), MSc, DPhil Yiangos Psaras - Oxford-BMS Post-Doctoral Research Fellow