Congratulations to Mafalda Da Cunha Santos.
Mafalda Santos is a molecular immunologist whose research has focused on how T cells detect and process information through the T cell receptor and its co-receptors. She obtained her PhD from the University of Porto under Professor Alexandre Carmo and has been based at the MRC Weatherall Institute of Molecular Medicine, University of Oxford, since 2013, working with Professor Simon Davis.
Her work integrates biophysics, super-resolution imaging, and molecular and structural biology to uncover the mechanisms underlying immune receptor triggering. She has contributed to major advances in understanding how receptor-ligand interactions and nanoscale cell-cell contacts shape early T cell activation and immune decision-making.
Mafalda is a co-applicant on a Wellcome Trust Discovery Award, supporting research that builds directly on these findings. Her research aims to define the molecular and physical principles governing lymphocytes activation and downstream signalling, with the goal of informing new approaches to modulate immune responses in cancer, autoimmunity, and infection.
Criteria for being a designated a Principal Investigator in RDM
Researchers are eligible to apply for PI designation if they meet one of the following criteria:
- Holds an intermediate level fellowship awarded in open competition from a major external funder;
- Holds significant funding in their own name, including as Co-Investigator, commensurate with their field of work and awarded in open competition from external funders;
- Has been awarded the title of University Research Lecturer (URL) or Associate Professor (AP) or holds a more senior appointment.
In addition, researchers must also demonstrate via their current CV that they have substantial independent achievements in research and teaching, and make contributions to 'good citizenship' within RDM and the wider University.
More information about the role of PI in RDM and applying for PI status can be found on the Principal Investigator Guidelines webpages.