Contact information
Research groups
Ashleigh King
EMBO Postdoctoral Fellow
I moved to Oxford and joined the Genome Integrity Lab as a Post-Doc in March 2019. I am interested in understanding immune cell development and function. My research uses the immune system to model 53BP1 pathway-dependent double strand break repair processes that are essential for development, diversity and preventing diseases such as cancer. I completed my BBiomedSc in Cell and Molecular Biology at Deakin University before completing my BSc (Hons) at the University of Melbourne (St Vincent’s Institute) with A/Prof. Jörg Heierhorst, where I studied the role of Asciz in the regulation of lung development. I remained at St Vincent’s Institute and completed my PhD with A/Prof. Jörg Heierhorst in 2018, investigating the role of Asciz and Dynein light chain-1 in embryonic development with a focus on B-cell development and primary cilia signalling.
Recent publications
Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice.
Journal article
King A. et al, (2025), Nat Struct Mol Biol, 32, 86 - 97
53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis.
Journal article
Mirman Z. et al, (2022), Nat Cell Biol, 24, 51 - 61
The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-κB Pathway Activation.
Journal article
Liu R. et al, (2021), Mol Cell Biol, 41
Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia.
Journal article
King A. et al, (2019), Hum Mol Genet, 28, 2573 - 2588
Multivalency regulates activity in an intrinsically disordered transcription factor.
Journal article
Clark S. et al, (2018), Elife, 7