Mary-Anne Durin
Postdoctoral Researcher
I started my DPhil project in the Chapman lab in October 2020.
My project focuses on understanding the molecular mechanisms of the BRCA1-dependent 53BP1 exclusion for DNA double-strand break repair pathway choice and the role of the BRCA1-BARD1 complex in DNA repair. I am interested in studying the different BRCA1 and BARD1 protein domains and regions to understand how they interact with chromatin at DNA double-strand break sites.
Research groups
Websites
Key publications
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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.
Journal article
Tsukada K. et al, (2024), Mol Cell, 84, 640 - 658.e10
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Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Journal article
Yeow ZY. et al, (2020), Nature, 585, 447 - 452
Recent publications
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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.
Journal article
Tsukada K. et al, (2024), Mol Cell, 84, 640 - 658.e10
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Data from Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Other
Tamura N. et al, (2023)
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Data from Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Other
Tamura N. et al, (2023)
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Supplementary Material from Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Other
Tamura N. et al, (2023)
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Supplementary Material from Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Other
Tamura N. et al, (2023)