Tanja Davis
BSc (Hons); MSc; PhD
Postdoctoral Researcher
I completed BSc (Hons) and MSc degrees in Genetics and followed with a PhD in Physiology at Stellenbosch University, South Africa. I subsequently undertook a postdoctoral fellowship with Prof Willem de Villers at Stellenbosch University, investigating the role of the acute-phase protein serum amyloid A in colitis-associated colon cancer.
I have a passion for cancer research and my interests include the tumour microenvironment, specifically interactions with the innate immune system. This has led me to join the group of Prof Jan Rehwinkel in 2021, where my current research focuses on SAMHD1 and its role in activating innate immune sensing in a cancer setting.
Recent publications
Hypoxia drives HIF2-dependent reversible macrophage cell cycle entry.
Journal article
Meng B. et al, (2024), Cell Rep, 43
denosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.
Journal article
Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5
Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A.
Journal article
du Plessis M. et al, (2021), Cytokine Growth Factor Rev, 59, 71 - 83
Serum amyloid A and inflammasome activation: A link to breast cancer progression?
Journal article
Fourie C. et al, (2021), Cytokine Growth Factor Rev, 59, 62 - 70
Serum Amyloid A Promotes Inflammation-Associated Damage and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer.
Journal article
Davis TA. et al, (2021), Cell Mol Gastroenterol Hepatol, 12, 1329 - 1341