BSc (Hons), DPhil
Postdoctoral Research Scientist
I am a postdoctoral research fellow in Prof Keith Channon's laboratory in the Division of Cardiovascular Medicine. I completed my DPhil in 2014 in which I studied the role of endothelial cell Gch1 and tetrahydrobiopterin (BH4) biosynthesis in vascular function and blood pressure regulation. I am currently investigating the role of endothelial cell BH4-dependent NOS regulation in vascular adaptations and blood pressure regulation in normal pregnancy using a novel mouse model of endothelial cell BH4 deficiency (endothelial cell-targeted Gch1 knockout mouse).
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Douglas G. et al, (2018), Cardiovasc Res, 114, 1385 - 1399
Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.
Chuaiphichai S. et al, (2018), Hypertension, 72, 128 - 138
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.
Patel J. et al, (2018), Vascul Pharmacol
A new role for RGS-1 in vascular function and blood pressure regulation
Patel J. et al, (2018), CARDIOVASCULAR RESEARCH, 114, S88 - S88
Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II
Chuaiphichai S. et al, (2018), CARDIOVASCULAR RESEARCH, 114, S90 - S90