BSc (Hons), DPhil
Postdoctoral Research Scientist
I am a postdoctoral research fellow in Prof Keith Channon's laboratory in the Division of Cardiovascular Medicine. I completed my DPhil in 2014 in which I studied the role of endothelial cell Gch1 and tetrahydrobiopterin (BH4) biosynthesis in vascular function and blood pressure regulation. I am currently investigating the role of endothelial cell BH4-dependent NOS regulation in vascular adaptations and blood pressure regulation in normal pregnancy using a novel mouse model of endothelial cell BH4 deficiency (endothelial cell-targeted Gch1 knockout mouse).
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.
Chuaiphichai S. et al, (2021), Hypertension
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.
Akoumianakis I. et al, (2020), Sci Transl Med, 12
Novel direct effects of SGLT2 inhibitor, Canagliflozin, on myocardial redox state in humans
Kondo H. et al, (2019), EUROPEAN HEART JOURNAL, 40, 3872 - 3872
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.
Patel J. et al, (2018), Vascul Pharmacol, 108, 15 - 22
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Douglas G. et al, (2018), Cardiovasc Res, 114, 1385 - 1399