Contact information
Shijie Cai
Associate Professor of Experimental Cancer Medicine
- Member of Steering Committee of Global Cholangiocarcinoma Alliance
- Doctor of Philosophy (PhD) - Gene Therapy, University of Cambridge
- Master of Philosophy (MPhil) - Paediatric Viral Respiratory Infection, University of Liverpool
- Clinical Research Fellow - Paediatric Infectious Diseases, Alder-Hey Children Hospital, University of Liverpool
- Doctor of Medicine - Tongji Medical University, China
Integrative omics analysis and target development for various cancer types
Our research interests lie in studying the molecular mechanisms of the tumour microenvironment and target development. We focus on the impact of metabolism and epigenetic regulation on crosstalk between stromal cells and tumour cells. The ongoing investigated tumours include colorectal cancer, breast cancer, pancreatic cancer and cholangiocarcinoma.
GROUP MEMBERS:
Medina Abudula - Post-doctoral Research Assistant
Galina Boskh - DPhil student
Xinyi Gao - DPhil student
Tiago Felismino - MSc student
Kai Mosby - Medical Student (FHS Research Project)
Zihe Wang - Academic visitor (PhD student)
Liu Yang - Academic visitor
Key publications
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GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner.
Journal article
Wang Z. et al, (2023), Cancer Res
Recent publications
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Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells.
Journal article
Wang Z. et al, (2024), Elife, 12
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Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
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Supplementary Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
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Supplementary Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
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Supplementary Figures from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
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Supplementary Figures from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
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Data from GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner
Other
Wang Z. et al, (2023)
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Data from GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner
Other
Wang Z. et al, (2023)