Contact information
Research groups
Shijie Cai
MD PhD MPhil
Principal Investigator
- Member of Steering Committee of Global Cholangiocarcinoma Alliance
Metabolism and epigenetic regulation in the tumour microenvironment
Our research interests lie in studying the molecular mechanisms of the tumour microenvironment and the target development. We focus on the impact of metabolism and epigenetic regulation on crosstalk between stromal cells and tumour cells. The ongoing investigated tumours include colorectal cancer, breast cancer and cholangiocarcinoma.
GROUP MEMBERS:
Yao Jiang - Postdoctoral Researcher
Gemma Owen - DPhil student
Aik Seng Ng - DPhil student
Galina Boskh - DPhil student
Recent publications
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GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner.
Journal article
Wang Z. et al, (2023), Cancer Res
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Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
Journal article
Tian Y. et al, (2021), Cell Death Dis, 12
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GTP cyclohydrolase accelerates tumor progression through interaction with angiopoietin-1 in stromal fibroblasts and activation of Tie2 on breast cancer cells
Conference paper
CAI S. et al, (2017)
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GTP cyclohydrolase as a novel mechanism for tumour growth
Conference paper
CAI S. et al, (2017)
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Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.
Journal article
Chen L. et al, (2016), Oncotarget, 7, 9353 - 9367