Research groups
Colleges
Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Short-term high glucose culture potentiates pancreatic beta cell function.
Journal article
Rebelato E. et al, (2018), Sci rep, 8
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Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis.
Journal article
Tarasov AI. et al, (2018), Lab chip
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The somatostatin-secreting pancreatic δ-cell in health and disease.
Journal article
Rorsman P. and Huising MO., (2018), Nat rev endocrinol, 14, 404 - 414
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CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Journal article
Briant LJB. et al, (2018), Cell rep, 23, 3300 - 3311
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Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.
Journal article
Hamilton A. et al, (2018), Diabetes, 67, 1128 - 1139
ORCID
0000-0001-7578-0767