BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.
Hastoy B. et al, (2018), Sci rep, 8
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Knudsen JG. et al, (2018), Cell metab
Pancreatic alpha cells respond to glucose with a change in the frequency of intracellular calcium oscillations
Kellard JA. et al, (2018), Diabetologia, 61, S244 - S244
Short-term high glucose culture potentiates pancreatic beta cell function.
Rebelato E. et al, (2018), Sci rep, 8
Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis.
Tarasov AI. et al, (2018), Lab chip