Research groups
Colleges
Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Response to Comment on Satin et al. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830-836.
Journal article
Satin LS. and Rorsman P., (2020), Diabetes, 69, e12 - e13
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Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice.
Journal article
Chanclón B. et al, (2020), Int J Obes (Lond)
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'Resistance is futile?' - paradoxical inhibitory effects of KATP channel closure in glucagon-secreting α-cells.
Journal article
Zhang Q. et al, (2020), J Physiol
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Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet.
Journal article
Kellard JA. et al, (2020), Mol Metab, 40
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A method for the generation of human stem cell-derived alpha cells.
Journal article
Peterson QP. et al, (2020), Nat Commun, 11
ORCID
0000-0001-7578-0767