Research groups
Colleges
Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.
Journal article
Kim A. et al, (2021), Elife, 10
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Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells
Journal article
Hatamie A. et al, (2021), Angewandte Chemie
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Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells.
Journal article
Hatamie A. et al, (2020), Angew Chem Int Ed Engl
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Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.
Journal article
Oduori OS. et al, (2020), J Clin Invest
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The vascular architecture of the pancreatic islets: A homage to August Krogh.
Journal article
Muratore M. et al, (2020), Comp Biochem Physiol A Mol Integr Physiol, 252
ORCID
0000-0001-7578-0767