BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
A method for the generation of human stem cell-derived alpha cells.
Peterson QP. et al, (2020), Nat Commun, 11
"Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets.
Satin LS. et al, (2020), Diabetes, 69, 830 - 836
A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets.
Hodson DJ. and Rorsman P., (2020), Diabetes, 69, 864 - 866
β-cell secretory dysfunction: a key cause of type 2 diabetes.
Holman RR. et al, (2020), Lancet Diabetes Endocrinol, 8
Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population-based study.
Dybjer E. et al, (2020), Diabet Med