Research groups
Colleges
Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Journal article
Haythorne E. et al, (2019), Nat Commun, 10
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Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and glucagon-like peptide 1 (GLP-1) secretion and controls whole-body glucose homeostasis.
Conference paper
Veprik A. et al, (2019), DIABETIC MEDICINE, 36, 16 - 17
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Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Journal article
Knudsen JG. et al, (2019), Cell Metab, 29, 430 - 442.e4
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PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Journal article
Guida C. et al, (2019), EBioMedicine, 40, 67 - 76
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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Journal article
Vergari E. et al, (2019), Nat Commun, 10
ORCID
0000-0001-7578-0767