BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+Mobilization from Acidic Stores in Pancreatic α-Cells.
Hamilton A. et al, (2018), Diabetes
Biphasic voltage-dependent inactivation of human NaV1.3, 1.6 and 1.7 Na+channels expressed in rodent insulin-secreting cells.
Godazgar M. et al, (2018), J Physiol
α-cell glucokinase suppresses glucose-regulated glucagon secretion.
Basco D. et al, (2018), Nat Commun, 9
AP2? Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.
Gorvin CM. et al, (2018), Cell Rep, 22, 1054 - 1066
δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin.
Briant LJB. et al, (2018), J Physiol, 596, 197 - 215