BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
Haythorne E. et al, (2022), Nat Commun, 13
Hindbrain insulin controls feeding behavior.
Eerola K. et al, (2022), Mol Metab
Every islet matters: improving the impact of human islet research
Gloyn AL. et al, (2022), Nature Metabolism
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.
Ye Y. et al, (2022), Nat Commun, 13
Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue.
Bauzá-Thorbrügge M. et al, (2022), Mol Metab