BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Dwivedi OP. et al, (2019), Nat Genet
Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release.
Denwood G. et al, (2019), J Gen Physiol, 151, 1094 - 1115
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Haythorne E. et al, (2019), Nat Commun, 10
Acetyl-CoA-Carboxylase 1 (ACC1) plays a critical role in glucagon and glucagon-like peptide 1 (GLP-1) secretion and controls whole-body glucose homeostasis.
Veprik A. et al, (2019), DIABETIC MEDICINE, 36, 16 - 17
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Knudsen JG. et al, (2019), Cell Metab, 29, 430 - 442.e4