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Contact information

Email
patrik.rorsman@hmc.ox.ac.uk

Telephone
+44 (0)1865 857348

PA
Amara Jandu
amara.jandu@ocdem.ox.ac.uk

Research groups

Rorsman Group

Colleges

Harris Manchester College

Patrik Rorsman

BM, PhD, FRS, FMedSci

Professor of Diabetic Medicine

Diabetes, Insulin secretion

We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.

Recent publications

Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control.

Gao R. et al, (2026), Nat Metab, 8, 159 - 176

Stephen Ashcroft, 27 January 1942-28 November 2025 IN MEMORIAM

Ashcroft F. et al, (2026), DIABETOLOGIA

Metabolic and Paracrine Heterogeneity of Pancreatic Glucagon-Secreting α-Cells.

Dou H. et al, (2025), Diabetes, 74, 2307 - 2321

δ-Cells Control a Subset of β-Cells in Mouse Pancreatic Islets.

Miranda C. et al, (2025), Diabetes, 74, 2365 - 2374

Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes.

Hatami A. et al, (2025), Angew Chem Int Ed Engl, 64

More publications

ORCID

0000-0001-7578-0767