BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
The somatostatin-secreting pancreatic δ-cell in health and disease.
Rorsman P. and Huising MO., (2018), Nat Rev Endocrinol, 14, 404 - 414
CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Briant LJB. et al, (2018), Cell Rep, 23, 3300 - 3311
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.
Hamilton A. et al, (2018), Diabetes, 67, 1128 - 1139
Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells.
Godazgar M. et al, (2018), J Physiol, 596, 1601 - 1626
α-cell glucokinase suppresses glucose-regulated glucagon secretion.
Basco D. et al, (2018), Nat Commun, 9