Patrik Rorsman

• Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.

  Journal article

  Babinsky VN. et al, (2017), Endocrinology, 158, 2486 - 2502

• A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis.

  Journal article

  Hastoy B. et al, (2017), Sci Rep, 7

• Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes.

  Journal article

  Gandasi NR. et al, (2017), J Clin Invest, 127, 2353 - 2364

• A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion.

  Journal article

  Shigeto M. et al, (2017), J Mol Med (Berl), 95, 361 - 368

• Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.

  Journal article

  Philippaert K. et al, (2017), Nat Commun, 8

• Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells.

  Journal article

  Amisten S. et al, (2017), Endocr J, 64, 325 - 338

• Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.

  Journal article

  Brereton MF. et al, (2016), Nat Commun, 7

• Key matrix proteins within the pancreatic islet basement membrane are differentially digested during human islet isolation.

  Journal article

  Cross SE. et al, (2016), American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

• Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion.

  Journal article

  Collins SC. et al, (2016), Diabetes, 65, 1952 - 1961

• Angular Approach Scanning Ion Conductance Microscopy.

  Journal article

  Shevchuk A. et al, (2016), Biophys J, 110, 2252 - 2265

• PYY-dependent restoration of impaired insulin and glucagon secretion in type-2 diabetes following Roux-En-Y gastric bypass surgery

  Journal article

  Ramracheya D. et al, (2016), Cell Reports

• Glucagon secretion from pancreatic α-cells.

  Journal article

  Briant L. et al, (2016), Ups J Med Sci, 121, 113 - 119

• Improving the physiological realism of experimental models.

  Journal article

  Vinnakota KC. et al, (2016), Interface Focus, 6

• Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1.

  Journal article

  Tarasov AI. and Rorsman P., (2016), Cell Metab, 23, 8 - 10

• The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.

  Journal article

  Cane MC. et al, (2016), Cell Calcium, 59, 32 - 40

• High-content screening identifies a role for Na(+) channels in insulin production.

  Journal article

  Szabat M. et al, (2015), R Soc Open Sci, 2

• GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

  Journal article

  Shigeto M. et al, (2015), J Clin Invest, 125, 4714 - 4728

• Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

  Journal article

  Arredouani A. et al, (2015), J Biol Chem, 290, 21376 - 21392

• Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells.

  Journal article

  Wu B. et al, (2015), Proc Natl Acad Sci U S A, 112, 9996 - 10001

• RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.

  Journal article

  Chandra V. et al, (2014), Cell Rep, 9, 2206 - 2218

• Matthias Braun, 23 July 1966-16 November 2013.

  Journal article

  Rorsman P. and Zhang Q., (2014), Diabetologia, 57, 2431 - 2432

• Matthias Braun, 23 July 1966-16 November 2013

  Journal article

  Rorsman P. and Zhang Q., (2014), Diabetologia, 57, 2431 - 2432

• Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

  Journal article

  Zhang Q. et al, (2014), J Physiol, 592, 4677 - 4696

• Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.

  Journal article

  Gheni G. et al, (2014), Cell Rep, 9, 661 - 673

• Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

  Journal article

  Brereton MF. et al, (2014), DIABETOLOGIA, 57, S93 - S93

• Elevation of cAMP promotes an Epac2 dependent, L-type Ca2+-channel coupled, Ca2+-induced Ca2+ release in mouse alpha cells

  Journal article

  Zhang Q. et al, (2014), DIABETOLOGIA, 57, S253 - S253

• Biphasic nature of glucose-induced insulin secretion is independent on energy metabolism

  Journal article

  Tarasov AI. et al, (2014), DIABETOLOGIA, 57, S178 - S179

• ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

  Journal article

  Rorsman P. et al, (2014), Diabetologia, 57, 1749 - 1761

• Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.

  Journal article

  Brereton MF. et al, (2014), Nat Commun, 5

• MicroRNA-7a regulates pancreatic β cell function.

  Journal article

  Latreille M. et al, (2014), J Clin Invest, 124, 2722 - 2735

• RFX6 Regulates Insulin Secretion by Modulating Ca²⁺ Homeostasis in Human β Cells

  Journal article

  Chandra V. et al, (2014), Cell Reports, 9, 2206 - 2218

• ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: Similar functions but reciprocal effects on secretion

  Journal article

  Rorsman P. et al, (2014), Diabetologia, 57, 1749 - 1761

• Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

  Journal article

  Zhang Q. et al, (2013), Cell Metab, 18, 871 - 882

• GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion.

  Journal article

  Soni A. et al, (2013), Biochem Biophys Res Commun, 441, 643 - 648

• K<inf>ATP</inf> channels and islet hormone secretion: New insights and controversies

  Journal article

  Ashcroft FM. and Rorsman P., (2013), Nature Reviews Endocrinology, 9, 660 - 669

• GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion.

  Journal article

  Soni A. et al, (2013), Biochem Biophys Res Commun

• An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

  Journal article

  Amisten S. et al, (2013), Pharmacology and Therapeutics, 139, 359 - 391

• TCF7L2 and diabetes: a tale of two tissues, and of two species.

  Journal article

  McCarthy MI. et al, (2013), Cell Metab, 17, 157 - 159

• Regulation of insulin secretion in human pancreatic islets.

  Journal article

  Rorsman P. and Braun M., (2013), Annu Rev Physiol, 75, 155 - 179

• SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells.

  Journal article

  Kailey B. et al, (2012), Am J Physiol Endocrinol Metab, 303, E1107 - E1116

• Autocrine regulation of insulin secretion.

  Journal article

  Braun M. et al, (2012), Diabetes Obes Metab, 14 Suppl 3, 143 - 151

• Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.

  Journal article

  Rosengren AH. et al, (2012), Diabetes, 61, 1726 - 1733

• The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells.

  Journal article

  Salehi A. et al, (2012), Nutr Metab (Lond), 9

• Diabetes mellitus and the β cell: the last ten years.

  Journal article

  Ashcroft FM. and Rorsman P., (2012), Cell, 148, 1160 - 1171

• Regulation of calcium in pancreatic α- and β-cells in health and disease.

  Journal article

  Rorsman P. et al, (2012), Cell Calcium, 51, 300 - 308

• The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.

  Journal article

  Yashiro H. et al, (2012), J Pharmacol Exp Ther, 340, 483 - 489

• Regulation of calcium in pancreatic α- and β-cells in health and disease

  Journal article

  Rorsman P. et al, (2012), Cell Calcium, 51, 300 - 308

• Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans.

  Journal article

  Rorsman P. et al, (2011), Prog Biophys Mol Biol, 107, 224 - 235

• Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

  Journal article

  Walker JN. et al, (2011), Diabetes Obes Metab, 13 Suppl 1, 95 - 105

• Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion

  Journal article

  MacDonald PE. and Rorsman P., (2011), Diabetologia, 54, 719 - 721

• Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content.

  Journal article

  Galvanovskis J. et al, (2011), Interface Focus, 1, 143 - 152

• Multivesicular exocytosis in rat pancreatic beta cells

  Journal article

  Hoppa MB. et al, (2011), Diabetologia, 1 - 12

• Glucose-responsive beta cells in islets isolated from a patient with long-standing type 1 diabetes mellitus

  Journal article

  Walker JN. et al, (2011), Diabetologia, 54, 200 - 202

• Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells.

  Journal article

  Akhmedov D. et al, (2010), FASEB J, 24, 4613 - 4626

• The glucagon-producing alpha cell: an electrophysiologically exceptional cell.

  Journal article

  Braun M. and Rorsman P., (2010), Diabetologia, 53, 1827 - 1830

• Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

  Journal article

  Ramracheya R. et al, (2010), Diabetes, 59, 2198 - 2208

• GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

  Journal article

  De Marinis YZ. et al, (2010), Cell Metab, 11, 543 - 553

• SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1.

  Journal article

  Jeyabalan J. et al, (2010), PLoS One, 5

• Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.

  Journal article

  Collins SC. et al, (2010), Diabetes, 59, 1192 - 1201

• Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.

  Journal article

  De Marinis YZ. et al, (2010), Diabetologia, 53, 717 - 729

• CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.

  Journal article

  Reed AA. et al, (2010), Am J Physiol Renal Physiol, 298, F365 - F380

• Defective secretion of islet hormones in chromogranin-B deficient mice.

  Journal article

  Obermüller S. et al, (2010), PLoS One, 5

• Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.

  Journal article

  Rosengren AH. et al, (2010), Science, 327, 217 - 220

• Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

  Journal article

  Hoppa MB. et al, (2009), Cell Metab, 10, 455 - 465

• Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.

  Journal article

  Li DQ. et al, (2009), Cell Metab, 10, 309 - 315

• NALCN: a regulated leak channel.

  Journal article

  Gilon P. and Rorsman P., (2009), EMBO Rep, 10, 963 - 964

• Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.

  Journal article

  Williams SE. et al, (2009), Hum Mol Genet, 18, 2963 - 2974

• Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

  Journal article

  Braun M. et al, (2009), Diabetologia, 52, 1566 - 1578

• Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.

  Journal article

  Olofsson CS. et al, (2009), Endocrinology, 150, 3067 - 3075

• Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs.

  Journal article

  Karanauskaite J. et al, (2009), Pflugers Arch, 458, 389 - 401

• miR-375 maintains normal pancreatic alpha- and beta-cell mass.

  Journal article

  Poy MN. et al, (2009), Proc Natl Acad Sci U S A, 106, 5813 - 5818

• Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function.

  Journal article

  Gloyn AL. et al, (2009), Diabetes, 58, 800 - 802

• The insulin receptor talks to glucagon?

  Journal article

  Gromada J. et al, (2009), Cell Metab, 9, 303 - 305

• Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.

  Journal article

  Hanna ST. et al, (2009), Pflugers Arch, 457, 1343 - 1350

• Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.

  Journal article

  Gustavsson N. et al, (2009), J Physiol, 587, 1169 - 1178

• Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.

  Journal article

  Mårtensson UE. et al, (2009), Endocrinology, 150, 687 - 698

• Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.

  Journal article

  Sumara G. et al, (2009), Cell, 136, 235 - 248

• Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

  Journal article

  Girard CA. et al, (2009), J Clin Invest, 119, 80 - 90

• Exocytotic properties of human pancreatic beta-cells.

  Journal article

  Braun M. et al, (2009), Ann N Y Acad Sci, 1152, 187 - 193

• Regulation of insulin granule exocytosis

  Chapter

  Renström E. and Rorsman P., (2008), Pancreatic Beta Cell in Health and Disease, 147 - 176

• PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

  Journal article

  Zehetner J. et al, (2008), Genes Dev, 22, 3135 - 3146

• Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans.

  Journal article

  Zhang Q. et al, (2008), Philos Trans A Math Phys Eng Sci, 366, 3503 - 3523

• K(ATP)-channels and glucose-regulated glucagon secretion.

  Journal article

  Rorsman P. et al, (2008), Trends Endocrinol Metab, 19, 277 - 284

• Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.

  Journal article

  Collins SC. et al, (2008), Diabetologia, 51, 1689 - 1693

• Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

  Journal article

  Wallis RH. et al, (2008), PLoS One, 3

• Quantification of mRNA in single cells and modelling of RT-qPCR induced noise.

  Journal article

  Bengtsson M. et al, (2008), BMC Mol Biol, 9

• Novel aspects of the molecular mechanisms controlling insulin secretion.

  Journal article

  Eliasson L. et al, (2008), J Physiol, 586, 3313 - 3324

• Probability of Exocytosis in Pancreatic β-Cells: Dependence on Ca2+ Sensing Latency Times, Ca2+ Channel Kinetic Parameters, and Channel Clustering

  Journal article

  Galvanovskis J. et al, (2008), 299 - 311

• Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

  Journal article

  Braun M. et al, (2008), Diabetes, 57, 1618 - 1628

• CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.

  Journal article

  Speidel D. et al, (2008), Cell Metab, 7, 57 - 67

• The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

  Journal article

  Gerken T. et al, (2007), Science, 318, 1469 - 1472

• Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

  Journal article

  Olofsson CS. et al, (2007), Diabetes, 56, 1888 - 1897

• Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

  Journal article

  Nielsen LB. et al, (2007), Eur J Endocrinol, 156, 663 - 671

• A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

  Journal article

  MacDonald PE. et al, (2007), PLoS biology, 5

• A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

  Journal article

  MacDonald PE. et al, (2007), PLoS Biol, 5

• The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

  Journal article

  MacDonald PE. and Rorsman P., (2007), Physiology (Bethesda), 22, 113 - 121

• R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

  Journal article

  Zhang Q. et al, (2007), Nat Cell Biol, 9, 453 - 460

• Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: evidence for the existence of insulinotropic agents in the stomach.

  Journal article

  Salehi A. et al, (2007), Regul Pept, 139, 31 - 38

• Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.

  Journal article

  Braun M. et al, (2007), J Gen Physiol, 129, 221 - 231

• A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.

  Journal article

  Jeans AF. et al, (2007), Proc Natl Acad Sci U S A, 104, 2431 - 2436

• Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

  Journal article

  MacDonald PE. et al, (2006), Cell Metab, 4, 283 - 290

• Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells.

  Journal article

  Vikman J. et al, (2006), J Mol Endocrinol, 36, 503 - 515

• Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

  Journal article

  MacDonald PE. and Rorsman P., (2006), PLoS biology, 4

• Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

  Journal article

  MacDonald PE. and Rorsman P., (2006), PLoS Biol, 4

• Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate.

  Journal article

  Taneera J. et al, (2006), Diabetes, 55, 290 - 296

• Glucose-sensing mechanisms in pancreatic beta-cells.

  Conference paper

  MacDonald PE. et al, (2005), Philos Trans R Soc Lond B Biol Sci, 360, 2211 - 2225

• Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.

  Journal article

  MacDonald PE. et al, (2005), J Cell Sci, 118, 5911 - 5920

• Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels.

  Journal article

  Bengtsson M. et al, (2005), Genome Res, 15, 1388 - 1392

• Selective nucleotide-release from dense-core granules in insulin-secreting cells.

  Journal article

  Obermüller S. et al, (2005), J Cell Sci, 118, 4271 - 4282

• Insulin secretion: Function and therapy of pancreatic beta-cells in diabetes

  Journal article

  Rorsman P., (2005), British Journal of Diabetes and Vascular Disease, 5, 187 - 191

• Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

  Journal article

  MacDonald PE. et al, (2005), Diabetes, 54, 736 - 743

• Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.

  Journal article

  Ma X. et al, (2005), Mol Endocrinol, 19, 198 - 212

• CaV2.3 calcium channels control second-phase insulin release.

  Journal article

  Jing X. et al, (2005), J Clin Invest, 115, 146 - 154

• Insulin secretion: a high-affinity Ca2+ sensor after all?

  Journal article

  Barg S. and Rorsman P., (2004), J Gen Physiol, 124, 623 - 625

• Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

  Journal article

  Gromada J. et al, (2004), Basic Clin Pharmacol Toxicol, 95, 252 - 262

• ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.

  Conference paper

  Gromada J. et al, (2004), Diabetes, 53 Suppl 3, S181 - S189

• A pancreatic islet-specific microRNA regulates insulin secretion.

  Journal article

  Poy MN. et al, (2004), Nature, 432, 226 - 230

• Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.

  Journal article

  Olofsson CS. et al, (2004), Diabetes, 53, 2836 - 2843

• New insights into the regulation of glucagon secretion by glucagon-like peptide-1.

  Journal article

  Gromada J. and Rorsman P., (2004), Horm Metab Res, 36, 822 - 829

• GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.

  Journal article

  Braun M. et al, (2004), J Physiol, 559, 397 - 409

• Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

  Journal article

  Kanno T. et al, (2004), Methods, 33, 302 - 311

• Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.

  Journal article

  Fex M. et al, (2004), Endocrinology, 145, 3746 - 3753

• The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.

  Journal article

  Hansson K. et al, (2004), J Biol Chem, 279, 32453 - 32463

• Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.

  Journal article

  Olofsson CS. et al, (2004), J Physiol, 557, 935 - 948

• Molecular defects in insulin secretion in type-2 diabetes.

  Journal article

  Ashcroft FM. and Rorsman P., (2004), Rev Endocr Metab Disord, 5, 135 - 142

• Isoform-specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L-type Ca²⁺ channels

  Journal article

  Sinnegger-Brauns MJ. et al, (2004), Journal of Clinical Investigation, 113, 1430 - 1439

• Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.

  Journal article

  Sinnegger-Brauns MJ. et al, (2004), J Clin Invest, 113, 1430 - 1439

• Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

  Journal article

  Göpel S. et al, (2004), J Physiol, 556, 711 - 726

• Type 2 diabetes mellitus: not quite exciting enough?

  Journal article

  Ashcroft F. and Rorsman P., (2004), Hum Mol Genet, 13 Spec No 1, R21 - R31

• Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.

  Journal article

  Wendt A. et al, (2004), Diabetes, 53, 1038 - 1045

• Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

  Journal article

  Braun M. et al, (2004), J Gen Physiol, 123, 191 - 204

• Insulin granule dynamics in pancreatic beta cells.

  Journal article

  Rorsman P. and Renström E., (2003), Diabetologia, 46, 1029 - 1045

• Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.

  Journal article

  Schulla V. et al, (2003), EMBO J, 22, 3844 - 3854

• Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.

  Journal article

  Olsen HL. et al, (2003), Proc Natl Acad Sci U S A, 100, 5187 - 5192

• Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

  Journal article

  Høy M. et al, (2003), Eur J Pharmacol, 466, 213 - 221

• SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.

  Journal article

  Eliasson L. et al, (2003), J Gen Physiol, 121, 181 - 197

• Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation.

  Journal article

  Kanno T. et al, (2002), J Physiol, 545, 501 - 507

• Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.

  Journal article

  Gromada J. et al, (2002), Eur J Endocrinol, 147, 133 - 142

• Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.

  Journal article

  Olofsson CS. et al, (2002), Pflugers Arch, 444, 43 - 51

• Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet.

  Journal article

  Kanno T. et al, (2002), Neurosci Res, 42, 79 - 90

• A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.

  Conference paper

  Barg S. et al, (2002), Diabetes, 51 Suppl 1, S74 - S82

• Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells.

  Journal article

  Barg S. et al, (2002), Neuron, 33, 287 - 299

• Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.

  Journal article

  Barg S. et al, (2001), Biophys J, 81, 3308 - 3323

• Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.

  Journal article

  Gromada J. et al, (2001), J Physiol, 535, 519 - 532

• Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.

  Journal article

  Barg S. et al, (2001), J Cell Sci, 114, 2145 - 2154

• Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.

  Journal article

  Gromada J. et al, (2001), Pflugers Arch, 442, 19 - 26

• Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials.

  Journal article

  Larsson-Nyrén G. et al, (2001), Pflugers Arch, 441, 587 - 595

• Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.

  Journal article

  Göpel SO. et al, (2000), J Physiol, 528, 509 - 520

• Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.

  Journal article

  Göpel SO. et al, (2000), J Physiol, 528, 497 - 507

• Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.

  Journal article

  Barg S. et al, (2000), Diabetes, 49, 1500 - 1510

• Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells.

  Journal article

  Høy M. et al, (2000), J Physiol, 527 Pt 1, 109 - 120

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