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Contact information

Email
martin.farrall@well.ox.ac.uk

Telephone
+44 (0)1865 287601

Martin Farrall

Emeritus Professor

I work with clinical groups to use both family and population-based studies to investigate the genetic component of complex cardiovascular and cerebrovascular diseases

familial coronary artery disease (CAD) - PROCARDIS with Hugh Watkins and Rory Collins and with the CARDIoGRAMplusC4D Consortium
inherited cardiomyopathies with Hugh Watkins
ischemic stroke - WTCCC2 and METASTROKE with Peter Rothwell and Hugh Markus
essential hypertension - MRC BRIGHT project and the Wellcome Trust Case Control Consortium (WTCCC1)
pre-eclampsia - GOPEC and WTCCC3
congenital heart disease - WTCCC3 with Shoumo Bhattacharya

Key publications

comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Nikpay M. et al, (2015), Nat Genet, 47, 1121 - 1130

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Do R. et al, (2015), Nature, 518, 102 - 106

genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.

Coronary Artery Disease (C4D) Genetics Consortium ., (2011), Nat Genet, 43, 339 - 344

Genetic variants associated with Lp(a) lipoprotein level and coronary disease.

Clarke R. et al, (2009), N Engl J Med, 361, 2518 - 2528

Recent publications

Data-driven modelling of mutational hotspots and in silico predictors in hypertrophic cardiomyopathy.

Waring A. et al, (2021), J Med Genet, 58, 556 - 564

Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome.

McGurk KA. et al, (2021), Hum Mol Genet, 30, 500 - 513

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.

Harper AR. et al, (2021), Nat Genet, 53, 135 - 142

Heritability of haemodynamics in the ascending aorta.

McGurk KA. et al, (2020), Sci Rep, 10

Reevaluation of the South Asian MYBPC3Δ25bp Intronic Deletion in Hypertrophic Cardiomyopathy.

Harper AR. et al, (2020), Circ Genom Precis Med, 13

More publications