Leanne Hodson

• Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study.

  Conference paper

  Hodson L. et al, (2017), Eur J Clin Nutr, 71, 973 - 979

• A Single Day of Excessive Dietary Fat Intake Reduces Whole-Body Insulin Sensitivity: The Metabolic Consequence of Binge Eating.

  Journal article

  Parry SA. et al, (2017), Nutrients, 9

• A cellular model for the investigation of depot specific human adipocyte biology.

  Journal article

  Todorčević M. et al, (2017), Adipocyte, 6, 40 - 55

• Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO).

  Journal article

  Nikolaou N. et al, (2016), Physiol Rep, 4

• Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III.

  Journal article

  Ooi EM. et al, (2016), Eur J Clin Invest, 46, 730 - 736

• Independent role of circulating glucose, NEFA and insulin on glucose and lipid metabolism in skeletal muscle and adipose tissue

  Conference paper

  Guzzardi MA. et al, (2016), DIABETOLOGIA, 59, S245 - S246

• Fatty acid trafficking in familial partial lipodystrophy: discovery of a new pathological pathway for the generation of non-esterified fatty acids

  Conference paper

  Karpe F. et al, (2016), DIABETOLOGIA, 59, S323 - S324

• Fasting plasma insulin concentrations are associated with changes in hepatic fatty acid synthesis and partitioning prior to changes in liver fat content in healthy adults

  Conference paper

  Hodson L. et al, (2016), DIABETOLOGIA, 59, S314 - S314

• Effect of overfeeding diets enriched with unsaturated or saturated fatty acids or sugars on de novo lipogenesis, lipolysis and liver fat in humans

  Conference paper

  Luukkonen PK. et al, (2016), DIABETOLOGIA, 59, S10 - S11

• Fasting Plasma Insulin Concentrations Are Associated With Changes in Hepatic Fatty Acid Synthesis and Partitioning Prior to Changes in Liver Fat Content in Healthy Adults.

  Journal article

  Pramfalk C. et al, (2016), Diabetes, 65, 1858 - 1867

• The combination of insulin resistance and the patatin-like phospholipase domain-containing protein-3 (PNPLA3) 148M (G allele variant) is associated with markedly higher levels of liver fat

  Journal article

  Scorletti E. et al, (2016), DIABETIC MEDICINE, 33, 28 - 29

• Effects of roux-en-Y gastric bypass surgery on postprandial fructose metabolism.

  Journal article

  Surowska A. et al, (2016), Obesity (Silver Spring), 24, 589 - 596

• Exercise performed immediately after fructose ingestion enhances fructose oxidation and suppresses fructose storage.

  Journal article

  Egli L. et al, (2016), Am J Clin Nutr, 103, 348 - 355

• Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.

  Journal article

  Hazlehurst JM. et al, (2016), J Clin Endocrinol Metab, 101, 103 - 113

• The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function.

  Journal article

  Todorčević M. and Hodson L., (2015), J Clin Med, 5

• Sex-Specific Differences in Hepatic Fat Oxidation and Synthesis May Explain the Higher Propensity for NAFLD in Men.

  Journal article

  Pramfalk C. et al, (2015), J Clin Endocrinol Metab, 100, 4425 - 4433

• Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women.

  Journal article

  Hodson L. et al, (2015), J Am Heart Assoc, 4

• Characterization of lipid metabolism in a novel immortalized human hepatocyte cell line.

  Journal article

  Green CJ. et al, (2015), Am J Physiol Endocrinol Metab, 309, E511 - E522

• The patatin-like phospholipase domain-containing protein 3 (PNPLA3) G allele variant (I148M) is associated with insulin resistance independently of diabetes status and liver fat quantity

  Journal article

  Scorletti ES. et al, (2015), DIABETIC MEDICINE, 32, 61 - 61

• From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations.

  Journal article

  Green CJ. et al, (2015), Am J Physiol Endocrinol Metab, 308, E1 - 20

• Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects

  Journal article

  Egli L. et al, (2015), Diabetes Technology and Therapeutics, 17, S94 - S95

• The influence of dietary fat on liver fat accumulation.

  Journal article

  Green CJ. and Hodson L., (2014), Nutrients, 6, 5018 - 5033

• Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study

  Journal article

  Scorletti E. et al, (2014), Hepatology, 60, 1211 - 1221

• Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome* study.

  Journal article

  Scorletti E. et al, (2014), Hepatology, 60, 1211 - 1221

• Independent effects of circulating glucose, insulin and NEFA on cardiac triacylglycerol accumulation and myocardial insulin resistance in a swine model.

  Journal article

  Guzzardi MA. et al, (2014), Diabetologia, 57, 1937 - 1946

• Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

  Journal article

  Tariq Z. et al, (2014), Liver Int, 34, e180 - e190

• Metabolic fate of fructose ingested with and without glucose in a mixed meal.

  Journal article

  Theytaz F. et al, (2014), Nutrients, 6, 2632 - 2649

• The storage stability and concentration of acetoacetate differs between blood fractions.

  Journal article

  McNeil CA. et al, (2014), Clin Chim Acta, 433, 278 - 283

• Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men

  Journal article

  Marinou K. et al, (2014), Diabetes Care, 37, 821 - 829

• Potential benefits of purified long chain omega-3 fatty acid treatment in non-alcoholic fatty liver disease (NAFLD): a potential treatment for early NAFLD in metabolic syndrome and Type 2 diabetes? Results from the WELCOME study

  Journal article

  Scorletti E. et al, (2014), DIABETIC MEDICINE, 31, 1 - 1

• Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men.

  Journal article

  Marinou K. et al, (2014), Diabetes Care, 37, 821 - 829

• Plasma and erythrocyte fatty acids reflect intakes of saturated and n-6 PUFA within a similar time frame.

  Journal article

  Hodson L. et al, (2014), J Nutr, 144, 33 - 41

• Lower resting and total energy expenditure in postmenopausal compared with premenopausal women matched for abdominal obesity.

  Journal article

  Hodson L. et al, (2014), J Nutr Sci, 3

• Independent effects of circulating glucose, insulin and NEFA on cardiac triacylglycerol accumulation and myocardial insulin resistance in a swine model

  Journal article

  Guzzardi MA. et al, (2014), Diabetologia, 57, 1937 - 1946

• Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

  Journal article

  Tariq Z. et al, (2014), Liver International, 34

• Adipose tissue oxygenation: Effects on metabolic function.

  Journal article

  Hodson L., (2014), Adipocyte, 3, 75 - 80

• Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.

  Journal article

  Hodson L. et al, (2013), Nutr Metab Cardiovasc Dis, 23, 1128 - 1133

• Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects

  Conference paper

  Egli L. et al, (2013), Diabetes, 62, 2259 - 2265

• Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects.

  Journal article

  Egli L. et al, (2013), Diabetes, 62, 2259 - 2265

• Metabolic signatures of human adipose tissue hypoxia in obesity.

  Journal article

  Hodson L. et al, (2013), Diabetes, 62, 1417 - 1425

• A study of hepatocyte ischaemia-reperfusion injury and steatosis in a human liver stem cell model

  Conference paper

  Sivathondan PC. et al, (2013), BRITISH JOURNAL OF SURGERY, 100, 23 - 23

• Whole-body and hepatic dietary fatty acid oxidation is related to postprandial insulin concentrations in people with non-alcoholic fatty liver disease with varying degrees of insulin resistance

  Journal article

  Hodson L. et al, (2013), DIABETIC MEDICINE, 30, 59 - 59

• Is there something special about palmitoleate?

  Journal article

  Hodson L. and Karpe F., (2013), Current Opinion in Clinical Nutrition and Metabolic Care, 16, 225 - 231

• Is there something special about palmitoleate?

  Journal article

  Hodson L. and Karpe F., (2013), Curr Opin Clin Nutr Metab Care, 16, 225 - 231

• Stearoyl-CoA desaturase: rogue or innocent bystander?

  Journal article

  Hodson L. and Fielding BA., (2013), Prog Lipid Res, 52, 15 - 42

• Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies

  Journal article

  Hodson L. et al, (2013), Nutrition, Metabolism and Cardiovascular Diseases, 23, 1128 - 1133

• Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.

  Journal article

  Theytaz F. et al, (2012), Am J Clin Nutr, 96, 1008 - 1016

• Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans

  Journal article

  Theytaz F. et al, (2012), American Journal of Clinical Nutrition, 96, 1008 - 1016

• Preeclampsia is associated with compromised maternal synthesis of long-chain polyunsaturated fatty acids, leading to offspring deficiency.

  Journal article

  Mackay VA. et al, (2012), Hypertension, 60, 1078 - 1085

• Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans.

  Journal article

  Pinnick KE. et al, (2012), Diabetes, 61, 1399 - 1403

• WAIST CIRCUMFERENCE GREATER THAN 90CM IS A RISK FACTOR FOR HEPATIC STEATOSIS IN OTHERWISE HEALTHY ADULTS - A 3 TESLA MAGNETIC RESONANCE SPECTROSCOPY STUDY

  Conference paper

  Banerjee R. et al, (2012), JOURNAL OF HEPATOLOGY, 56, S504 - S504

• De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation.

  Journal article

  Collins JM. et al, (2011), J Lipid Res, 52, 1683 - 1692

• Hepatic fatty acid partitioning.

  Journal article

  Hodson L. and Frayn KN., (2011), Curr Opin Lipidol, 22, 216 - 224

• Hepatic fatty acid partitioning

  Journal article

  Hodson L. and Frayn KN., (2011), Current Opinion in Lipidology, 22, 216 - 224

• Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice.

  Journal article

  van Diepen JA. et al, (2011), J Lipid Res, 52, 942 - 950

• Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca(2+) Channels from Secretory Granules.

  Journal article

  Hoppa MB. et al, (2011), Cell Metab, 13

• Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men

  Journal article

  Marinou K. et al, (2011), British Journal of Nutrition, 105, 857 - 865

• Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men.

  Journal article

  Marinou K. et al, (2011), Br J Nutr, 105, 857 - 865

• Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men.

  Journal article

  Marinou K. et al, (2011), The British journal of nutrition, 105, 857 - 865

• Serum fatty acid reference ranges: percentiles from a New Zealand national nutrition survey.

  Journal article

  Bradbury KE. et al, (2011), Nutrients, 3, 152 - 163

• Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

  Journal article

  McQuaid SE. et al, (2011), Diabetes, 60, 47 - 55

• A large waist circumference is associated with higher liver fat in healthy pre-menopausal women in the absence of classical biochemical risk factors for CVD

  Journal article

  Hodson L. et al, (2011), PROCEEDINGS OF THE NUTRITION SOCIETY, 70, E229 - E229

• Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.

  Journal article

  Westerbacka J. et al, (2010), Gastroenterology, 139, 1961 - 1971.e1

• Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease

  Journal article

  Westerbacka J. et al, (2010), Gastroenterology, 139

• Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?

  Journal article

  Hodson L. et al, (2010), Am J Physiol Endocrinol Metab, 299, E584 - E592

• Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids.

  Journal article

  McQuaid SE. et al, (2010), Diabetes, 59, 2465 - 2473

• Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD

  Conference paper

  Kotronen A. et al, (2010), DIABETOLOGIA, 53, S104 - S104

• Does the DASH diet lower blood pressure by altering peripheral vascular function?

  Journal article

  Hodson L. et al, (2010), J Hum Hypertens, 24, 312 - 319

• Dietary fat and insulin sensitivity.

  Journal article

  Frayn KN. et al, (2010), Diabetologia, 53, 799 - 801

• Trafficking and partitioning of fatty acids: The transition from fasted to fed state

  Journal article

  Hodson L. and Fielding BA., (2010), Clinical Lipidology, 5, 131 - 144

• Trafficking and partitioning of fatty acids: the transition from fasted to fed state

  Journal article

  Hodson L. and Fielding BA., (2010), CLINICAL LIPIDOLOGY, 5, 131 - 144

• SUBSTRATE UTILISATION BY THE FAILING HUMAN HEART BY DIRECT QUANTIFICATION USING ARTERIOVENOUS BLOOD SAMPLING

  Conference paper

  Funada J. et al, (2010), HEART, 96

• Dietary Approaches to Stop Hypertension (DASH) diet: applicability and acceptability to a UK population.

  Journal article

  Harnden KE. et al, (2010), J Hum Nutr Diet, 23, 3 - 10

• Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

  Journal article

  Hoppa MB. et al, (2009), Cell Metab, 10, 455 - 465

• Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling.

  Journal article

  Funada J. et al, (2009), PLoS One, 4

• Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.

  Journal article

  Roberts R. et al, (2009), Diabetologia, 52, 882 - 890

• Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage.

  Journal article

  Ruge T. et al, (2009), J Clin Endocrinol Metab, 94, 1781 - 1788

• Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate.

  Journal article

  Hodson L. et al, (2009), Am J Physiol Endocrinol Metab, 296, E64 - E71

• Fatty acid metabolism in patients with PPARgamma mutations.

  Journal article

  Tan GD. et al, (2008), J Clin Endocrinol Metab, 93, 4462 - 4470

• Regulation of fat storage in human subcutaneous adipose tissue over a 24-hour period

  Conference paper

  Karpe F. et al, (2008), DIABETOLOGIA, 51, S20 - S20

• Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake.

  Journal article

  Hodson L. et al, (2008), Prog Lipid Res, 47, 348 - 380

• Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake

  Journal article

  Hodson L. et al, (2008), Progress in Lipid Research, 47, 348 - 380

• Caution on the interpretation of plasma fatty acid composition as a proxy marker for SCD1 activity: particular implications for using the 16:1/16:0 ratio in QTL studies involving hyperlipidemic patients.

  Journal article

  Karpe F. and Hodson L., (2008), Arterioscler Thromb Vasc Biol, 28

• Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.

  Journal article

  Chong MF. et al, (2008), Am J Clin Nutr, 87, 817 - 823

• The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state.

  Journal article

  Hodson L. et al, (2007), Diabetes, 56, 2433 - 2441

• Sources of fatty acids for 3-hydroxybutyrate production differ during short-term fasting in men and women

  Conference paper

  Marinou K. et al, (2007), ATHEROSCLEROSIS SUPPLEMENTS, 8, 23 - 24

• Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.

  Conference paper

  Karpe F. et al, (2007), Biochem Soc Trans, 35, 472 - 476

• Insulin resistance reduces the contribution of systemic plasma non-esterified fatty acids into very low-density lipoprotein triacylglycerol

  Conference paper

  Hodson L. et al, (2007), ATHEROSCLEROSIS SUPPLEMENTS, 8, 9 - 10

• Abnormalities in fatty acid storage and delivery in the metabolic syndrome

  Conference paper

  Karpe F. et al, (2007), INTERNATIONAL JOURNAL OF OBESITY, 31, S6 - S6

• Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period.

  Journal article

  Bickerton AS. et al, (2007), Diabetes, 56, 168 - 176

• Dietary fat is a major contributor to VLDL production in the fed state in humans

  Conference paper

  Hodson L. et al, (2006), ATHEROSCLEROSIS, 188, S3 - S4

• Human myocardial substrate utilization in compensated heart failure; increased lactate extraction as an alternative energy source to fatty acids

  Conference paper

  Funada JF. et al, (2006), EUROPEAN HEART JOURNAL, 27, 483 - 483

• De novo lipogenesis (DNL) occurs after a 3-day eucaloric low-fat, high-carbohydrate (HC) solid food diet

  Conference paper

  Chong MFF. et al, (2006), FASEB JOURNAL, 20, A1022 - A1023

• Dietary-induced changes in fatty acid composition of human plasma, platelet, and erythrocyte lipids follow a similar time course.

  Journal article

  Skeaff CM. et al, (2006), J Nutr, 136, 565 - 569

• Use of a stable isotope technique to estimate postprandial chylomicron triacylglycerol concentrations without physical separation of the particles

  Conference paper

  Fielding BA. et al, (2005), DIABETOLOGIA, 48, A197 - A197

• Incorporation of exogenous and endogenous fatty acids into very low-density lipoprotein (VLDL): a study using stable isotope and immunoaffinity techniques in humans

  Conference paper

  Hodson L. et al, (2005), DIABETOLOGIA, 48, A233 - A233

• Maximal response to a plasma cholesterol-lowering diet is achieved within two weeks.

  Journal article

  Hodson L. et al, (2002), Nutr Metab Cardiovasc Dis, 12, 291 - 295

• Stability of plasma and erythrocyte fatty acid composition during cold storage.

  Journal article

  Hodson L. et al, (2002), Clin Chim Acta, 321, 63 - 67

• The effect of replacing dietary saturated fat with polyunsaturated or monounsaturated fat on plasma lipids in free-living young adults.

  Journal article

  Hodson L. et al, (2001), Eur J Clin Nutr, 55, 908 - 915

• The isolation of primary hepatocytes from human tissue: optimising the use of small non-encapsulated liver resection surplus

  Journal article

  Green C. et al, Cell and Tissue Banking

• The influence of dietary macronutrients on liver fat accumulation and metabolism

  Journal article

  Hodson L. and Parry S., Journal of Investigative Medicine

Recent Publications

• Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study.

  Conference paper

  Hodson L. et al, (2017), Eur J Clin Nutr, 71, 973 - 979

• A Single Day of Excessive Dietary Fat Intake Reduces Whole-Body Insulin Sensitivity: The Metabolic Consequence of Binge Eating.

  Journal article

  Parry SA. et al, (2017), Nutrients, 9

• A cellular model for the investigation of depot specific human adipocyte biology.

  Journal article

  Todorčević M. et al, (2017), Adipocyte, 6, 40 - 55

• Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO).

  Journal article

  Nikolaou N. et al, (2016), Physiol Rep, 4

• Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III.

  Journal article

  Ooi EM. et al, (2016), Eur J Clin Invest, 46, 730 - 736