Joseph Clarke

I am a Postdoctoral Scientist working with Professor Simon Davis' T-Cell Biology group and Dr. Sumana Sharma's Mechanistic T-Cell Genomics Group within the MRC Translational Immune Discovery Unit (TIDU). Broadly, I am interested in how interactions at the cell membrane influence T-cell decision-making. My current research focuses on uncovering the signalling networks that enable inhibitory receptor activity in CD8+ T-cells and identifying genetic mediators of enhanced T-cell function, persistence, and fitness, using high-throughput CRISPR-Cas9 gene editing platforms to address these key questions.

Previously, I completed my PhD in April 2023 at the University of Birmingham, in the laboratories of Professor David Wraith and Professor Alicia El Haj, where I investigated the triggering mechanisms of the T-cell receptor (TCR).