Professor of Dermatology
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Quantification of dengue virus specific T cell responses and correlation with viral load and clinical disease severity in acute dengue infection.
Wijeratne DT. et al, (2018), Plos negl trop dis, 12
Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma.
Hilvering B. et al, (2018), Mucosal immunol, 11, 1408 - 1419
First-in-class phase 2a study of anb020 (anti-il-33) in the treatment of moderate-to-severe atopic dermatitis
Chen Y. et al, (2018), Allergy, 73, 77 - 77
Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response.
Stockenhuber K. et al, (2018), J exp med
Cutaneous bacterial sensing through group 2 innate lymphoid cell presentation of endogenous CD1a lipid antigens
Hardman C. et al, (2018), British journal of dermatology, 178, E403 - E403