Professor of Dermatology
CD1a; Skin immunology; T cells; innate lymphoid cells
CD1a, T cells and the skin
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Specifically, we are working on skin T cells which respond to inflammatory lipids that are presented by CD1a. This turns out to be a very important part skin immune responses and we have been defining the underlying mechanisms. Our findings are also developing towards new approaches to modulate the CD1a pathway for patient benefit.
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Chen Y-L. et al, (2023), Sci Immunol, 8
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls.
Zheng B. et al, (2023), Lancet Reg Health Eur, 29
Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination.
Yin Z. et al, (2023), Cell Rep, 42
Antibody and memory B cell responses to the dengue virus NS1 antigen in individuals with varying severity of past infection.
Ramu ST. et al, (2023), Immunology
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.
Jackson C. et al, (2023), Lancet Respir Med