Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation
Chen Y-L. et al, (2019), Journal of Experimental Medicine
Atopic dermatitis epidemiology and unmet need in the United Kingdom.
Cork MJ. et al, (2019), J Dermatolog Treat, 1 - 9
Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis.
Chen Y-L. et al, (2019), Science translational medicine, 11
Association of dengue virus-specific polyfunctional T-cell responses with clinical disease severity in acute dengue infection.
Wijeratne DT. et al, (2019), Immun Inflamm Dis
Use of T Cell-Specific RNA In Situ Hybridisation as a Novel Test to Distinguish Malignant (Lymphomatous) and Benign (Inflammatory) T Cell Infiltrates
Soilleux EJ. et al, (2019), JOURNAL OF PATHOLOGY, 249, S12 - S12