Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.
Fruchart J-C. et al, (2019), Cardiovasc Diabetol, 18
MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.
Hilton C. et al, (2019), EBioMedicine
Regional fat depot masses are influenced by protein-coding gene variants
Neville M. et al, (2019)
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
Erzurumluoglu AM. et al, (2019), Mol Psychiatry
The diabetes risk gene TCF7L2 regulates human adipose progenitor cell biology
Verma M. et al, (2018), DIABETOLOGIA, 61, S12 - S12