Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
The diabetes risk gene TCF7L2 regulates human adipose progenitor cell biology
Verma M. et al, (2018), Diabetologia, 61, S12 - S12
Cartilage oligomeric matrix protein is differentially expressed in human subcutaneous adipose tissue and regulates adipogenesis.
Denton N. et al, (2018), Mol metab, 16, 172 - 179
Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.
Lord SR. et al, (2018), Cell metab
Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Small KS. et al, (2018), Nat genet, 50
Relevance of human fat distribution on lipid and lipoprotein metabolism and cardiovascular disease risk.
Piché M-E. et al, (2018), Curr opin lipidol, 29, 285 - 292