Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
Corbin LJ. et al, (2018), Nat Commun, 9
Cohort Profile: The Oxford Biobank.
Karpe F. et al, (2018), Int J Epidemiol, 47, 21 - 21g
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Flannick J. et al, (2018), Sci Data, 5
Chylomicron-Derived Fatty Acid Spillover in Adipose Tissue: A Signature of Metabolic Health?
Piché M-E. et al, (2018), J Clin Endocrinol Metab, 103, 25 - 34
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V. et al, (2018), Nat Genet, 50, 26 - 41