Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
Oxford Laboratory for Integrative Physiology (Oxlip)
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
Prevalence, Incidence and predictors of cardiovascular risk factors-longitudianl study from rural and urban South India and comparison with global data
Vasan SK. et al, (2020)
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
Loh NY. et al, (2020), Nat Commun, 11
LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity
Loh N. et al, (2020)
Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism.
Green CJ. et al, (2020), BMJ Open Diabetes Res Care, 8
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk.
International Multiple Sclerosis Genetics Consortium. Electronic address: firstname.lastname@example.org None. and International Multiple Sclerosis Genetics Consortium None., (2020), Cell, 180