Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
Oxford Laboratory for Integrative Physiology (Oxlip)
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
Polygenic risk in Type III hyperlipidaemia and risk of cardiovascular disease: An epidemiological study in UK Biobank and Oxford Biobank.
Pieri K. et al, (2022), Int J Cardiol
High-throughput mass spectrometry maps the sepsis plasma proteome and differences in response
Mi Y. et al, (2022)
Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia.
Jobe M. et al, (2022), Int J Obes (Lond)
HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution.
Kuo F-C. et al, (2022), Cell Rep, 40
The power of genetic diversity in genome-wide association studies of lipids.
Graham SE. et al, (2021), Nature