Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides.
Weir G. et al, (2018), Cell Metab, 27, 1348 - 1355.e4
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Small KS. et al, (2018), Nat Genet, 50, 572 - 580
Comparison of regional fat measurements by dual-energy X-ray absorptiometry and conventional anthropometry and their association with markers of diabetes and cardiovascular disease risk.
Vasan SK. et al, (2018), Int J Obes (Lond), 42, 850 - 857
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
Corbin LJ. et al, (2018), Nat Commun, 9
Cohort Profile: The Oxford Biobank.
Karpe F. et al, (2018), Int J Epidemiol, 47, 21 - 21g