Mass spectrometrist and chemist working in KJ’s lab. Optimising protocols to quantify DNA damage caused by aldehydes and the quantification of free aldehydes in blood and cells.
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9
CDK activity provides temporal and quantitative cues for organizing genome duplication
Perrot A. et al, (2018), PLOS Genetics, 14, e1007214 - e1007214
Bypass of Mutagenic O6-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases
Räz MH. et al, (2016), Chemical Research in Toxicology, 29, 1493 - 1503
Touching base with arginine: recognition of O6-alkyl guanines by alkyltransferase-like protein Atl1
Wilkinson O. et al, (2014), Collection Symposium Series
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations
Zhang F. et al, (2013), Nucleic Acids Research, 41, 5524 - 5532