Andrea van Dam
NOVO NORDISK POSTDOCTORAL RESEARCH FELLOW (2017-2021)
- Project: Unravelling the role of Hedgehog signalling in human obesity and body fat distribution
Andrea was awarded a Novo Nordisk Postdoctoral Fellowship starting in 2017, working with Dr Costas Christodoulides and Professor Fredrik Karpe in OCDEM. During her fellowship, she used human genetic and physiological approaches, accompanied by studies in cellular models to better understand the mechanisms by which genetic variants in developmental pathway genes modulate fat distribution. Her main project focused on a variant in the HHIP locus associated with fat distribution in GWAS. Paired abdominal and gluteal fat biopsies were obtained from human individuals that were recruited by genotype, and single-cell RNA-sequencing of the stromal vascular fraction was performed to identify celltype-specific mechanisms driving the phenotype.
Following her fellowship, Andrea will start specialist training for clinical biochemistry at the ETZ, JBZ and Radboud UMC hospitals in the Netherlands. In her new role, she is pursuing her dream of contributing directly to patient care while working in science.
Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states Liu J. et al, 2019, Biochim Biophys Acta Mol Cell Biol Lipid
Hedgehog signalling as a determinant of human fat expansion and distribution van Dam AD. et al, 2020
Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. Kuipers EN. et al, 2018, Int J Mol Sci
The GPR 120 agonist TUG ‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat Schilperoort M. et al, 2018, EMBO Molecular Medicine