Amin Mottahedin
MSc, PhD, FHEA
Senior Research Fellow
I work with Foster's lab at Nuffield Department of Clinical Neurosciences (NDCN) and Buchan’s lab at Radcliffe Department of Medicine to unravel the effect of circadian rhythm on stroke-induced brain injury. I am particularly interested in how metabolic responses to ischemia and hypoxia are affected by circadian rhythm.
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I worked as a veterinarian in my home country, Iran, before moving to Sweden to start my science career. I obtained a master’s degree in Infection Biology from Uppsala University and completed my PhD in Medical Sciences from University of Gothenburg (Mallard's lab). During my PhD, I investigated how infection/ inflammation affects the developing brain and exacerbates the hypoxic-ischemic brain injury. After receiving an international postdoc fellowship from Swedish Research Council, I joined Murphy's & Krieg's lab at MRC Mitochondrial Biology Unit, University of Cambridge, where we were able to identify mitochondrial succinate metabolism as a potential therapeutic target in ischemic stroke.
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Recent publications
2-deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat
Preprint
Boehm-Sturm P. et al, (2025)
Stroke in the Time of Circadian Medicine.
Journal article
Mergenthaler P. et al, (2024), Circ Res, 134, 770 - 790
Two different isoforms of osteopontin modulate myelination and axonal integrity.
Journal article
Nilsson G. et al, (2023), FASEB Bioadv, 5, 336 - 353
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Journal article
Mottahedin A. et al, (2023), Redox Biol, 59
ND3 Cys39 in complex I is exposed during mitochondrial respiration.
Journal article
Burger N. et al, (2022), Cell Chem Biol, 29, 636 - 649.e14
