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Research by Prof Andrew Wilkie and Prof Anne Goriely, published in PNAS, has identified the origins of some severe disease-causing mutations within the testicles of normal men. Particular mutations in the FGFR2 gene and a few other disease genes enable the mutated spermatogonia to produce not just sperm but extra copies of themselves, reproducing and spreading faster than the surrounding normal spermatogonia. This tumour-like growth means that over time, a greater proportion of sperm being produced carry disease-causing mutations, increasing the risk of fathering a child with a serious condition.
Chris Groves
Administration IMD MRC MHU Research Support WIMM
BSc (Hons) Chris Groves - MRC MHU Laboratory Manager
Simon Davis
IMD MRC TIDU Principal Investigators
BSc (Hons), PhD Simon Davis - Professor of Molecular Immunology
Alain Townsend
Emeritus Professors IMD MRC TIDU WIMM
FRS FRCP Alain Townsend - Emeritus Professor of Molecular Immunology
Timothy Rostron
IMD MRC TIDU Research Support
BSc; MSc Timothy Rostron - Sequencing and HLA Typing Laboratory Manager
Jan Rehwinkel
IMD MRC TIDU Principal Investigators
PhD Jan Rehwinkel - Professor of Innate Immunology