DTU Publications (1970-1999)

1999

Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47).

Adler AI. et al, (1999), Am Heart J, 138, S353 - S359

Metformin and risk of cardiovascular disease.

Turner RC. and Holman RR., (1999), Cardiology, 91, 203 - 204

Microaneurysms in the development of diabetic retinopathy (UKPDS 42). UK Prospective Diabetes Study Group.

Kohner EM. et al, (1999), Diabetologia, 42, 1107 - 1112

UKPDS: what was the question? UK Prospective Diabetes Study.

Turner R. et al, (1999), Lancet, 354

andomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44).

Holman RR. et al, (1999), Diabetes Care, 22, 960 - 964

Quality of life in type 2 diabetic patients is affected by complications but not by intensive policies to improve blood glucose or blood pressure control (UKPDS 37). U.K. Prospective Diabetes Study Group.

(1999), Diabetes Care, 22, 1125 - 1136

Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus. Progressive requirement for multiple therapies (UKPDS 49)

Turner RC. et al, (1999), Journal of the American Medical Association, 281, 2005 - 2012

Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group.

Horton V. et al, (1999), Diabetologia, 42, 608 - 616

1998

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group.

UK Prospective Diabetes Study Group ., (1998), BMJ, 317, 703 - 713

Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. UK Prospective Diabetes Study Group.

UK Prospective Diabetes Study Group ., (1998), BMJ, 317, 713 - 720

Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: UKPDS 40

Gray A., (1998), British Medical Journal, 317, 720 - 726

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

Turner R. et al, (1998), Lancet, 352, 837 - 853

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

Turner R. et al, (1998), Lancet, 352, 854 - 865

Ethnicity and cardiovascular disease. The incidence of myocardial infarction in white, South Asian, and Afro-Caribbean patients with type 2 diabetes (U.K. Prospective Diabetes Study 32).

(1998), Diabetes Care, 21, 1271 - 1277

ssessing the potential for alpha-glucosidase inhibitors in prediabetic states.

Holman RR., (1998), Diabetes Res Clin Pract, 40 Suppl, S21 - S25

Changes in amylin and amylin-like peptide concentrations and beta-cell function in response to sulfonylurea or insulin therapy in NIDDM.

Rachman J. et al, (1998), Diabetes Care, 21, 810 - 816

UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years

Matthews DR. et al, (1998), Diabetic Medicine, 15, 297 - 303

Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23).

Turner RC. et al, (1998), BMJ, 316, 823 - 828

United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors.

Kohner EM. et al, (1998), Arch Ophthalmol, 116, 297 - 303

United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. United Kingdom Prospective Diabetes Study Group.

(1998), Ann Intern Med, 128, 165 - 175

UKPDS 28: A randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes

Wright AD. et al, (1998), Diabetes Care, 21, 87 - 92

1997

The Fasting Hyperglycaemia Study: I. Subject identification and recruitment for a non-insulin-dependent diabetes prevention trial.

Hammersley MS. et al, (1997), Metabolism, 46, 44 - 49

The Fasting Hyperglycaemia Study: II. Randomized controlled trial of reinforced healthy-living advice in subjects with increased but not diabetic fasting plasma glucose.

Dyson PA. et al, (1997), Metabolism, 46, 50 - 55

UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes

Turner R. et al, (1997), LANCET, 350, 1288 - 1293

U.K. Prospective Diabetes Study 27. Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex.

(1997), Diabetes Care, 20, 1683 - 1687

pproach to maintaining comparability of biochemical data during long-term clinical trials.

Cull CA. et al, (1997), Clin Chem, 43, 1913 - 1918

U.K. Prospective Diabetes Study 22. Effect of age at diagnosis on diabetic tissue damage during the first 6 years of NIDDM.

Davis TM. et al, (1997), Diabetes Care, 20, 1435 - 1441

Coronary heart disease and risk factors in NIDDM--experience from the United Kingdom Prospective Diabetes Study.

Turner RC. et al, (1997), Diabetologia, 40 Suppl 2, S121 - S122

UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects.

Widjaja A. et al, (1997), J Clin Endocrinol Metab, 82, 654 - 657

1996

High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population.

Saker PJ. et al, (1996), Diabetologia, 39, 1325 - 1328

Hypertension in Diabetes Study IV. Therapeutic requirements to maintain tight blood pressure control.

(1996), Diabetologia, 39, 1554 - 1561

The UK Prospective Diabetes Study

Turner RC. and Holman RR., (1996), Annals of Medicine, 28, 439 - 444

Randomized controlled pilot trial of a hand-held patient-oriented, insulin regimen optimizer

Holman RR. et al, (1996), Medical Informatics, 21, 317 - 326

UKPDS 18: Estimated dietary intake in type 2 diabetic patients randomly allocated to diet, sulphonylurea or insulin therapy

Eeley EA. et al, (1996), DIABETIC MEDICINE, 13, 656 - 662

Frequency of hypoglycemic episodes during intensive therapy with human insulin.

Tubner RC. et al, (1996), Diabetes Care, 19, 181 - 182

U.K. prospective diabetes study.

Tubner RC. et al, (1996), Diabetes Care, 19, 182 - 183

United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus.

Turner R. et al, (1996), Ann Intern Med, 124, 136 - 145

1995

United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years.

(1995), BMJ, 310, 83 - 88

UK prospective diabetes study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM.

Keavney BD. et al, (1995), Diabetologia, 38, 948 - 952

Lessons from UK prospective diabetes study.

Turner RC. and Holman RR., (1995), Diabetes Res Clin Pract, 28 Suppl, S151 - S157

Insulin therapy in type II diabetes.

Holman RR. and Turner RC., (1995), Diabetes Res Clin Pract, 28 Suppl, S179 - S184

1994

Hypertension in Diabetes Study. III. Prospective study of therapy of hypertension in type 2 diabetic patients: efficacy of ACE inhibition and beta-blockade.

(1994), Diabet Med, 11, 773 - 782

UK Prospective Diabetes Study. XII: Differences between Asian, Afro-Caribbean and white Caucasian type 2 diabetic patients at diagnosis of diabetes. UK Prospective Diabetes Study Group.

(1994), Diabet Med, 11, 670 - 677

UK Prospective Diabetes Study (UKPDS). XI: Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects.

(1994), Diabet Med, 11, 534 - 544

Optimized diabetes therapy knowledge-based systems: Safety critical issues

Nealon JL. et al, (1994), IEE Colloquium (Digest)

1993

vailability of type II diabetic families for detection of diabetes susceptibility genes.

Cook JT. et al, (1993), Diabetes, 42, 1536 - 1543

UK Prospective Diabetes Study (UKPDS). X. Urinary albumin excretion over 3 years in diet-treated type 2, (non-insulin-dependent) diabetic patients, and association with hypertension, hyperglycaemia and hypertriglyceridaemia.

(1993), Diabetologia, 36, 1021 - 1029

UK Prospective Diabetes Study (UKPDS). IX: Relationships of urinary albumin and N-acetylglucosaminidase to glycaemia and hypertension at diagnosis of type 2 (non-insulin-dependent) diabetes mellitus and after 3 months diet therapy.

(1993), Diabetologia, 36, 835 - 842

Hypertension in Diabetes Study (HDS): I. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications.

(1993), J Hypertens, 11, 309 - 317

Hypertension in Diabetes Study (HDS): II. Increased risk of cardiovascular complications in hypertensive type 2 diabetic patients.

(1993), J Hypertens, 11, 319 - 325

1991

UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance.

(1991), Diabetologia, 34, 877 - 890

Post-prandial glycaemic reduction by an alpha-glucosidase inhibitor in type 2 diabetic patients with therapeutically attained basal normoglycaemia.

Holman RR. et al, (1991), Diabetes Res, 18, 149 - 153

antibodies to islet amyloid polypeptide in diabetes.

Clark A. et al, (1991), Diabet Med, 8, 668 - 673

1990

Rapid restoration of normoglycaemia using intravenous insulin boluses.

Dunnett JM. et al, (1990), Diabetes Res, 15, 151 - 155

Insulin use in NIDDM. Rationale based on pathophysiology of disease.

Turner RC. and Holman RR., (1990), Diabetes Care, 13, 1011 - 1020

UK Prospective Diabetes Study 7: response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients, UKPDS Group.

(1990), Metabolism, 39, 905 - 912

1988

Optimizing blood glucose control in type 2 diabetes: an approach based on fasting blood glucose measurements.

Holman RR. and Turner RC., (1988), Diabet Med, 5, 582 - 588

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

Clark A. et al, (1988), Diabetes Res, 9, 151 - 159

Finger-prick blood samples: full blood counts in general practice.

Holman R., (1988), Practitioner, 232, 988 - 991

Diabetes mellitus and anaesthesia. A survey of the peri-operative management of the patient with diabetes mellitus.

Dunnet JM. et al, (1988), Anaesthesia, 43, 538 - 542

UK Prospective Diabetes Study. V. Characteristics of newly presenting type 2 diabetic patients: estimated insulin sensitivity and islet 4-cell function. Multi-centre study.

(1988), Diabet Med, 5, 444 - 448

Insulin for the non-insulin dependent?

Holman RR., (1988), Br Med J (Clin Res Ed), 296, 1469 - 1470

UK Prospective Diabetes Study. IV. Characteristics of newly presenting type 2 diabetic patients: male preponderance and obesity at different ages. Multi-center Study.

(1988), Diabet Med, 5, 154 - 159

1987

Sulphonylurea failure in type 2 diabetes: treatment with a basal insulin supplement.

Holman RR. et al, (1987), Diabet Med, 4, 457 - 462

Type II diabetes of early onset: a distinct clinical and genetic syndrome?

O'Rahilly S. et al, (1987), Br Med J (Clin Res Ed), 294, 923 - 928

Pen-sized digital 30-second blood glucose meter.

Matthews DR. et al, (1987), Lancet, 1, 778 - 779

Glycosylated haemoglobin measurement on blood samples taken by patients: an additional aid to assessing diabetic control.

Holman RR. et al, (1987), Diabet Med, 4, 71 - 73

Quantitative modelling of endocrine diseases as exemplified by diabetes.

Turner RC. et al, (1987), Clin Endocrinol (Oxf), 26, 107 - 116

No glycemic benefit from guar administration in NIDDM.

Holman RR. et al, (1987), Diabetes Care, 10, 68 - 71

[Treatment of non-insulin-dependent diabetes].

Turner RC. and Holman RR., (1987), Journ Annu Diabetol Hotel Dieu, 291 - 301

1986

Quantifying early diabetic retinopathy.

Howard-Williams JR. et al, (1986), Diabetologia, 29, 761 - 766

Diabetes nomenclature: classification or grading of severity?

Turner RC. et al, (1986), Diabet Med, 3, 216 - 220

Glycosylated haemoglobin: comparison of five different methods, including measurement on capillary blood samples.

Moore JC. et al, (1986), Ann Clin Biochem, 23 ( Pt 1), 85 - 91

1985

The Christmas feast.

Rees SG. et al, (1985), Br Med J (Clin Res Ed), 291, 1764 - 1765

United Kingdom Prospective Diabetes Study. III. Prevalence of hypertension and hypotensive therapy in patients with newly diagnosed diabetes. A multicenter study.

(1985), Hypertension, 7, II8 - I13

U.K. Prospective Diabetes Study: II. Reduction in HbA1c with Basal Insulin Supplement, Sulfonylurea, or Biguanide Therapy in Maturity-onset Diabetes

(1985), Diabetes, 34, 793 - 798

Continuous infusion of glucose with model assessment: measurement of insulin resistance and beta-cell function in man.

Hosker JP. et al, (1985), Diabetologia, 28, 401 - 411

Patient-orientated metered capillary blood collection.

Holman RR. et al, (1985), Ann Clin Biochem, 22 ( Pt 2), 141 - 143

Physiology of insulin secretion: problems of quantity and timing.

Matthews DR. et al, (1985), Neth J Med, 28 Suppl 1, 20 - 24

practical guide to basal and prandial insulin therapy.

Holman RR. and Turner RC., (1985), Diabet Med, 2, 45 - 53

1984

Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients.

Clark A. et al, (1984), Diabetologia, 27, 527 - 528

Insulin treatment of maturity onset diabetes.

Turner RC. and Holman RR., (1984), Minerva Endocrinol, 9, 233 - 240

Human ultralente insulin.

Holman RR. et al, (1984), Br Med J (Clin Res Ed), 288, 665 - 668

1983

UK prospective study of therapies of maturity-onset diabetes. I. Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight over one year.

(1983), Diabetologia, 24, 404 - 411

Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study.

Holman RR. et al, (1983), Lancet, 1, 204 - 208

1982

egular meal and insulin infusion regimen: its use in the treatment of acute-onset ketotic diabetes and in stabilization of poorly controlled established diabetic subjects.

Davis TM. et al, (1982), Diabetes Care, 5, 492 - 496

Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes.

Turner RC. et al, (1982), Lancet, 1, 596 - 598

Vibration sensory threshold: a guide to adequacy of dialysis?

Read DJ. et al, (1983), Proc Eur Dial Transplant Assoc, 19, 253 - 257

1981

Insulin infusion pump.

Holman RR. and Turner RC., (1981), Lancet, 2

The basal plasma glucose: a simple relevant index of maturity-onset diabetes.

Holman RR. and Turner RC., (1981), Clin Endocrinol (Oxf), 14, 279 - 286

1980

Fasting blood glucose concentrations and treatment of maturity-onset diabetes.

Howe-Davies S. et al, (1980), Br Med J, 280

Survival in sinoatrial disorder (sick-sinus syndrome).

Shaw DB. et al, (1980), Br Med J, 280, 139 - 141

1979

Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations.

Turner RC. et al, (1979), Metabolism, 28, 1086 - 1096

simple and rational twice daily insulin regime. Distinction between basal and meal insulin requirements.

Phillips M. et al, (1979), Q J Med, 48, 493 - 506

Maintenance of Basal Plasma Glucose and Insulin Concentrations in Maturity-Onset Diabetes

Holman RR. and Turner RC., (1979), Diabetes, 28, 227 - 230

1978

Home blood sampling for plasma glucose assay in control of diabetes.

Howe-Davies S. et al, (1978), Br Med J, 2, 596 - 598

Basal normoglycemia attained with chlorpropamide in mild diabetes.

Holman RR. and Turner RC., (1978), Metabolism, 27, 539 - 547

betacell function during insulin or chlorpropamide treatment of maturity-onset diabetes mellitus.

Turner RC. and Holman RR., (1978), Diabetes, 27 Suppl 1, 241 - 246

Serum lipids in treated diabetic children and their families.

Mann JI. et al, (1978), Clin Endocrinol (Oxf), 8, 27 - 33

matic lancet for capillary blood sampling.

Turner RC. and Holman RR., (1978), Lancet, 2

1977

Diabetes: The quest for basal normoglycaemia.

Holman RR. and Turner RC., (1977), Lancet, 1, 469 - 474

Treatment of type IV hypertriglyceridaemia with insulin

Turner RC. et al, (1977), Clinical Science and Molecular Medicine, 53

1976

Pathophysiology of diabetes.

Turner RC. and Holman RR., (1976), Lancet, 2

Insulin rather than glucose homoeostasis in the pathophysiology of diabetes.

Turner RC. and Holman RR., (1976), Lancet, 1, 1272 - 1274

Beta-cell function improved by supplementing basal insulin secretion in mild diabetes.

Turner RC. et al, (1976), Br Med J, 1, 1252 - 1254

1975

Early life of the 'battered child'.

Holman RR. and Kanwar S., (1975), Arch Dis Child, 50, 78 - 80

PAST PUBLICATIONS

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