Research groups
Cansu Dinçer
Postdoctoral Scientist
I am a Postdoctoral Scientist in Dr Sumana Sharma’s Mechanistic T Cell Genomics Group within the MRC Translational Immune Discovery Unit. As a computational biologist, I am broadly interested in systems biology, particularly in understanding how signalling networks are rewired across cellular contexts and how this knowledge can be leveraged to reprogram cells.
Previously, I completed my PhD in Dr Mathew Garnett’s Translational Cancer Genomics Laboratory at the Wellcome Sanger Institute and the University of Cambridge, where I focused on inferring effective cancer combination therapies through multi-omics integration and network modelling.
Key publications
Base editing screens define the genetic landscape of cancer drug resistance mechanisms.
Journal article
Coelho MA. et al, (2024), Nat Genet, 56, 2479 - 2492
Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells.
Journal article
Usluer S. et al, (2023), Stem Cell Reports, 18, 1061 - 1074
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model.
Journal article
Degirmenci B. et al, (2021), iScience, 24
CEN-tools: an integrative platform to identify the contexts of essential genes.
Journal article
Sharma S. et al, (2020), Mol Syst Biol, 16
3D spatial organization and network-guided comparison of mutation profiles in Glioblastoma reveals similarities across patients.
Journal article
Dincer C. et al, (2019), PLoS Comput Biol, 15
Recent publications
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments
Preprint
Dinçer C. et al, (2025)
Base editing screens define the genetic landscape of cancer drug resistance mechanisms.
Journal article
Coelho MA. et al, (2024), Nat Genet, 56, 2479 - 2492
Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells.
Journal article
Picco G. et al, (2024), Cancer Discov, 14, 1457 - 1475
Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells.
Journal article
Usluer S. et al, (2023), Stem Cell Reports, 18, 1061 - 1074
Base editing screens map mutations affecting interferon-γ signaling in cancer.
Journal article
Coelho MA. et al, (2023), Cancer Cell, 41, 288 - 303.e6
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model.
Journal article
Degirmenci B. et al, (2021), iScience, 24
CEN-tools: an integrative platform to identify the contexts of essential genes.
Journal article
Sharma S. et al, (2020), Mol Syst Biol, 16
3D spatial organization and network-guided comparison of mutation profiles in Glioblastoma reveals similarities across patients.
Journal article
Dincer C. et al, (2019), PLoS Comput Biol, 15