Research groups
Cansu Dinçer
Postdoctoral Scientist
I am a Postdoctoral Scientist in Dr Sumana Sharma’s Mechanistic T Cell Genomics Group within the MRC Translational Immune Discovery Unit. As a computational biologist, I am broadly interested in systems biology, particularly in understanding how signalling networks are rewired across cellular contexts and how this knowledge can be leveraged to reprogram cells.
Previously, I completed my PhD in Dr Mathew Garnett’s Translational Cancer Genomics Laboratory at the Wellcome Sanger Institute and the University of Cambridge, where I focused on inferring effective cancer combination therapies through multi-omics integration and network modelling.
Key publications
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Base editing screens define the genetic landscape of cancer drug resistance mechanisms
Journal article
Coelho MA. et al, (2024), Nature Genetics, 56, 2479 - 2492
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CEN-tools: an integrative platform to identify the contexts of essential genes.
Journal article
Sharma S. et al, (2020), Mol Syst Biol, 16
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Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
Journal article
Degirmenci B. et al, (2021), iScience, 24, 103369 - 103369
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Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells
Journal article
Usluer S. et al, (2023), Stem Cell Reports, 18, 1061 - 1074
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3D spatial organization and network-guided comparison of mutation profiles in Glioblastoma reveals similarities across patients
Journal article
Dincer C. et al, (2019), PLOS Computational Biology, 15, e1006789 - e1006789
Recent publications
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BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments
Preprint
Dinçer C. et al, (2025)
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Base editing screens define the genetic landscape of cancer drug resistance mechanisms
Journal article
Coelho MA. et al, (2024), Nature Genetics, 56, 2479 - 2492
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Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells
Journal article
Picco G. et al, (2024), Cancer Discovery, 14, 1457 - 1475
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Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells
Journal article
Usluer S. et al, (2023), Stem Cell Reports, 18, 1061 - 1074
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Base editing screens map mutations affecting interferon-γ signaling in cancer
Journal article
Coelho MA. et al, (2023), Cancer Cell, 41, 288 - 303.e6
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Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
Journal article
Degirmenci B. et al, (2021), iScience, 24, 103369 - 103369
-
CEN-tools: an integrative platform to identify the contexts of essential genes.
Journal article
Sharma S. et al, (2020), Mol Syst Biol, 16
-
3D spatial organization and network-guided comparison of mutation profiles in Glioblastoma reveals similarities across patients
Journal article
Dincer C. et al, (2019), PLOS Computational Biology, 15, e1006789 - e1006789