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Bowen Zhang
D.Phil.
Postdoctoral Researcher
Haematopoietic stem cell biology and ageing
Haematopoietic stem cells (HSCs) are rare, self-renewing cells that sustain lifelong blood and immune cell production. Understanding how these cells function and change with age is essential for tackling age-related immune decline, blood disorders and improving regenerative therapies.
My research focuses on the molecular and functional heterogeneity of HSCs, particularly how ageing influences lineage bias and regenerative potential. I integrate single-cell multi-omics, machine learning, and transplantation assays to characterise HSC compartment clonal dynamic and functional decline.
As part of my DPhil work, I identified surface markers for FACS-based isolation of lineage-biased HSCs with unprecedented precision, and uncovered novel molecular targets to precisely counteract haematopoietic ageing.
I to graduated in summer 2025 and will continue studying mouse and human HSC ageing using advanced computational and molecular approaches.
Recent publications
Epigenetic programming defines haematopoietic stem cell fate restriction.
Journal article
Meng Y. et al, (2023), Nat Cell Biol, 25, 812 - 822
