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Alastair Smith
Postdoctoral Researcher
Brief biography and current research interests
I joined the Milne Lab in 2018 after completing my PhD, where I investigated the temporal regulation of transcription in V(D)J recombination. My current research focuses on the emergence and function of novel enhancers in leukaemia, with a particular emphasis on MLL-AF4 Acute Lymphoblastic Leukaemia (ALL).
To investigate chromatin regulation and gene expression, I apply a broad suite of high-throughput and integrative approaches. These include ChIP-seq, low-input ChIPmentation, ATAC-seq, RNA-seq, Capture-C, CUT&Tag, single-cell multiomics, and DNA methylation profiling. I combine these data with machine learning and advanced bioinformatic methods to uncover mechanisms of transcriptional dysregulation in leukaemia.