Contact information

Telephone
+44 (0) 1865 222412 (Renata Sojka)

PA
Renata Sojka
renata.sojka@rdm.ox.ac.uk

Research groups

Simmons Group: Intestinal Immunity in Health and Disease

DPhil Projects Available

2026 Simmons Group: Engineering Intestinal Mesenchymal Niches to Promote Epithelial Barrier Health Through Life — Radcliffe Department of Medicine

Alison Simmons

PhD FRCP FMedSci

Director of the MRC Translational Immune Discovery Unit

Consultant Physician
Professor of Gastroenterology

Key publications

Spatial fibroblast niches define Crohn's fistulae.

McGregor C. et al, (2026), Nature, 649, 703 - 712

Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis.

Gupta T. et al, (2024), Cancer Cell, 42, 797 - 814.e15

Spatiotemporal analysis of human intestinal development at single-cell resolution.

Fawkner-Corbett D. et al, (2021), Cell, 184, 810 - 826.e23

Single-cell atlas of colonic CD8+ T cells in ulcerative colitis.

Corridoni D. et al, (2020), Nat Med, 26, 1480 - 1490

Colonic epithelial cell diversity in health and inflammatory bowel disease.

Parikh K. et al, (2019), Nature, 567, 49 - 55

Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets.

Aulicino A. et al, (2018), Nat Commun, 9

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.

Kinchen J. et al, (2018), Cell, 175, 372 - 386.e17

Recent publications

Spatial fibroblast niches define Crohn's fistulae.

McGregor C. et al, (2026), Nature, 649, 703 - 712

Correction: Spatial fibroblast niches define Crohn's fistulae.

McGregor C. et al, (2025), Nature, 648

Immune-epithelial-stromal networks define the cellular ecosystem of the small intestine in celiac disease.

FitzPatrick MEB. et al, (2025), Nat Immunol, 26, 947 - 962

Type I IFN-activated lung monocytes and macrophages as initiators and drivers of fibrosis at the alveolar barrier in IPF

Nathwani V. et al, (2025)

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease.

Windster JD. et al, (2025), Gastroenterology, 168, 965 - 979.e12

Goblet cell differentiation subgroups in colorectal cancer.

Abdullayeva G. et al, (2024), Proc Natl Acad Sci U S A, 121

Biologic Therapy for Inflammatory Bowel Disease: Real-World Comparative Effectiveness and Impact of Drug Sequencing in 13 222 Patients within the UK IBD BioResource.

Kapizioni C. et al, (2024), J Crohns Colitis, 18, 790 - 800

Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.

Chanchlani N. et al, (2024), Lancet Gastroenterol Hepatol, 9, 521 - 538

Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis.

Gupta T. et al, (2024), Cancer Cell, 42, 797 - 814.e15

Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients.

Bai BYH. et al, (2024), J Crohns Colitis, 18, 431 - 445

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.

Rana N. et al, (2024), Cell, 187, 1011 - 1015

HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis.

Baumdick ME. et al, (2023), Gastroenterology, 165, 946 - 962.e13

bust deep learning workflow to predict CD8 + T-cell epitopes.

Lee CH. et al, (2023), Genome Med, 15

Roadmap for the Human Gut Cell Atlas.

Zilbauer M. et al, (2023), Nat Rev Gastroenterol Hepatol, 20, 597 - 614

nti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease.

Hanić M. et al, (2023), Biomolecules, 13

Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.

Matute JD. et al, (2023), J Exp Med, 220

systems approach evaluating the impact of SARS-CoV-2 variant of concern mutations on CD8+ T cell responses.

Buckley PR. et al, (2023), Immunother Adv, 3

Pathogenesis of Fistulating Crohn's Disease: A Review.

McGregor CGC. et al, (2023), Cell Mol Gastroenterol Hepatol, 15, 1 - 11

Lymphatic endothelia stakeout cryptic stem cells.

Antanaviciute A. et al, (2022), Cell Stem Cell, 29, 1292 - 1293

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.

Sazonovs A. et al, (2022), Nat Genet, 54, 1275 - 1283

Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.

Serra EG. et al, (2022), Nat Commun, 13

Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens.

Buckley PR. et al, (2022), Brief Bioinform, 23

HLA-dependent variation in SARS-CoV-2 CD8 + T cell cross-reactivity with human coronaviruses.

Buckley PR. et al, (2022), Immunology, 166, 78 - 103

Multicentre derivation and validation of a colitis-associated colorectal cancer risk prediction web tool.

Curtius K. et al, (2022), Gut, 71, 705 - 715

Dual RNA sequencing reveals dendritic cell reprogramming in response to typhoidal Salmonella invasion.

Aulicino A. et al, (2022), Commun Biol, 5

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.

Rana N. et al, (2022), Cell, 185, 283 - 298.e17

bust deep learning platform to predict CD8+ T-cell epitopes

Lee C. et al, (2022)

Isolation of human fetal intestinal cells for single-cell RNA sequencing.

Fawkner-Corbett D. et al, (2021), STAR Protoc, 2

Interferon-Gamma-Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor-Colitis.

Sasson SC. et al, (2021), Gastroenterology, 161, 1229 - 1244.e9

Pilot Study on Automatic Three-Dimensional Quantification of Barrett's Esophagus for Risk Stratification and Therapy Monitoring.

Ali S. et al, (2021), Gastroenterology, 161, 865 - 878.e8

Common heritage of fibroblasts.

Antanaviciute A. et al, (2021), Nat Immunol, 22, 944 - 946

Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration.

Koppens MAJ. et al, (2021), Gastroenterology, 161, 239 - 254.e9

IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent.

Hardman CS. et al, (2021), Sci Immunol, 6

Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource.

Stournaras E. et al, (2021), Gut, 70, 677 - 686

Spatiotemporal analysis of human intestinal development at single-cell resolution.

Fawkner-Corbett D. et al, (2021), Cell, 184, 810 - 826.e23

Correction: A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals.

Demetriou P. et al, (2021), Nat Immunol, 22

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.

Fraser E. et al, (2021), Front Immunol, 12

HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses

Buckley P. et al, (2021)

FAECAL MICROBIOTA TRANSPLANT FOR REFRACTORY CHECKPOINT INHIBITOR IMMUNOTHERAPY-RELATED COLITIS

Cheung V. et al, (2021), GUT, 70, A89 - A89

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.

Moreira LM. et al, (2020), Nature, 587, 460 - 465

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.

Moreira LM. et al, (2020), Nature, 587, 460 - 465

Inflammatory Bowel Disease Through the Lens of Single-cell RNA-seq Technologies.

Corridoni D. et al, (2020), Inflamm Bowel Dis, 26, 1658 - 1668

Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model.

Gibani MM. et al, (2020), PLoS Negl Trop Dis, 14

dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals.

Demetriou P. et al, (2020), Nat Immunol, 21, 1232 - 1243

Single-cell atlas of colonic CD8+ T cells in ulcerative colitis.

Corridoni D. et al, (2020), Nat Med, 26, 1480 - 1490

Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.

Preciado-Llanes L. et al, (2020), Proc Natl Acad Sci U S A, 117, 20717 - 20728

Calcitonin paracrine signaling controls atrial fibrogenesis and arrhythmia

MOREIRA LM. et al, (2020), Nature

Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.

Bulek K. et al, (2020), J Clin Invest, 130, 4218 - 4234

Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?

Cheung VTF. et al, (2020), Br J Cancer, 123, 207 - 215

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.

Serra EG. et al, (2020), Nat Commun, 11

Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?

Tran F. et al, (2020), Front Immunol, 11

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Sazonovs A. et al, (2020), Gastroenterology, 158, 189 - 199

Potential CD8+ T Cell Cross-Reactivity Against SARS-CoV-2 Conferred by Other Coronavirus Strains.

Lee CH. et al, (2020), Front Immunol, 11

Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors.

Lee CH. et al, (2020), Front Immunol, 11

Remission of Inflammatory Bowel Disease in Glucose-6-Phosphatase 3 Deficiency by Allogeneic Haematopoietic Stem Cell Transplantation.

Bolton C. et al, (2020), J Crohns Colitis, 14, 142 - 147

IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?

Cheung VT. et al, (2020), GASTROENTEROLOGY, 158, S535 - S536

Immune checkpoint inhibitor-related colitis assessment and prognosis: can inflammatory bowel disease scoring point the way?

Cheung VTF. et al, (2020), JOURNAL OF CROHNS & COLITIS, 14, S286 - S288

Immunotherapy-related hepatitis: real-world experience from a tertiary centre.

Cheung V. et al, (2019), Frontline Gastroenterol, 10, 364 - 371

17th International Congress of Immunology, 19-23 October 2019, Beijing, China.

(2019), Eur J Immunol, 49 Suppl 3, 1 - 2223

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.

Harnack C. et al, (2019), Nat Commun, 10

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.

Leng T. et al, (2019), Cell Rep, 28, 3077 - 3091.e5

IBD BioResource: an open-access platform of 25 000 patients to accelerate research in Crohn's and Colitis.

Parkes M. and IBD BioResource Investigators ., (2019), Gut, 68, 1537 - 1540

Innate immune receptors for cross-presentation: The expanding role of NLRs.

Corridoni D. and Simmons A., (2019), Mol Immunol, 113, 6 - 10

Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses.

Abd Hamid M. et al, (2019), Cancer Immunol Res, 7, 1293 - 1306

Single-Cell and Time-Resolved Profiling of Intracellular Salmonella Metabolism in Primary Human Cells.

Xu J. et al, (2019), Anal Chem, 91, 7729 - 7737

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.

Kennedy NA. et al, (2019), Lancet Gastroenterol Hepatol, 4, 341 - 353

Becalming Type 17 Inflammation in Ulcerative Colitis.

Chen HH. and Simmons A., (2019), Immunity, 50, 1029 - 1031

The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies.

Gibani MM. et al, (2019), Clin Infect Dis, 68, 1265 - 1273

Publisher Correction: Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.

Napolitani G. et al, (2019), Nat Immunol, 20

Cannabis, Cannabinoids, and the Endocannabinoid System-Is there Therapeutic Potential for Inflammatory Bowel Disease?

Ambrose T. and Simmons A., (2019), J Crohns Colitis, 13, 525 - 535

Colonic epithelial cell diversity in health and inflammatory bowel disease.

Parikh K. et al, (2019), Nature, 567, 49 - 55

ssociation of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

Walker GJ. et al, (2019), JAMA, 321, 773 - 785

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses.

Corridoni D. et al, (2019), Front Immunol, 10

axin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.

Chapman TP. et al, (2019), Front Immunol, 10

icanSalmonellaTyphimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB

Preciado-Llanes L. et al, (2019)

Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets.

Aulicino A. et al, (2018), Nat Commun, 9

Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis.

Probert F. et al, (2018), J Crohns Colitis, 12, 1326 - 1337

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.

Kinchen J. et al, (2018), Cell, 175, 372 - 386.e17

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.

Napolitani G. et al, (2018), Nat Immunol, 19, 742 - 754

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.

Schwerd T. et al, (2018), Mucosal Immunol, 11, 562 - 574

The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease.

Kennedy NA. et al, (2018), Inflamm Bowel Dis, 24, 583 - 592

practical solution for preserving single cells for RNA sequencing.

Attar M. et al, (2018), Sci Rep, 8

Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease.

Corridoni D. et al, (2018), Front Med (Lausanne), 5

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells.

Kurioka A. et al, (2018), Front Immunol, 9

Young adults living with inflammatory bowel disease. A thematic synthesis of patient experience

Fourie S. et al, (2018), JOURNAL OF CROHNS & COLITIS, 12, S583 - S583

TrueColours ulcerative colitis (TCUC): Will patients with UC complete digital questionnaires in real-time?

Walsh A. et al, (2018), JOURNAL OF CROHNS & COLITIS, 12, S286 - S286

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.

Zinecker H. et al, (2017), Oncotarget, 8, 106764 - 106777

Benzimidazoles Promote Anti-TNF Mediated Induction of Regulatory Macrophages and Enhance Therapeutic Efficacy in a Murine Model.

Wildenberg ME. et al, (2017), J Crohns Colitis, 11, 1480 - 1490

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.

Bao L. et al, (2017), Sci Rep, 7

Microbiome, pattern recognition receptor function in health and inflammation.

Fawkner-Corbett D. et al, (2017), Best Pract Res Clin Gastroenterol, 31, 683 - 691

Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.

Hegazy AN. et al, (2017), Gastroenterology, 153, 1320 - 1337.e16

Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.

Khatamzas E. et al, (2017), EMBO J, 36, 2998 - 3011

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

West NR. et al, (2017), Nat Med, 23, 579 - 589

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

Lee JC. et al, (2017), Nat Genet, 49, 262 - 268

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

Luo Y. et al, (2017), Nat Genet, 49, 186 - 192

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

de Lange KM. et al, (2017), Nat Genet, 49, 256 - 261

TCR-Identical CD8+T-Cells Can Have Distinct Killing Efficacy Determined By Events Beyond the T-Cell Receptor

Glanville JM. et al, (2017), BLOOD, 130

Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure.

Cahill TJ. et al, (2016), J Biol Chem, 291

protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA. et al, (2016), Nat Commun, 7

n integrative analysis of gene expression and molecular interaction data to identify dys-regulated sub-networks in inflammatory bowel disease.

Muraro D. and Simmons A., (2016), BMC Bioinformatics, 17

Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus.

Pichulik T. et al, (2016), Eur J Immunol, 46, 167 - 177

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.

Cahill TJ. et al, (2015), J Biol Chem, 290, 25907 - 25919

ssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

Liu JZ. et al, (2015), Nat Genet, 47, 979 - 986

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC. et al, (2015), Nat Genet, 47, 717 - 726

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

Goyette P. et al, (2015), Nat Genet, 47, 172 - 179

Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes.

Prescott NJ. et al, (2015), PLoS Genet, 11

Corrigendum: CD90(+) Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa.

Owens BMJ. et al, (2015), Front Immunol, 6

The relationship between miR-29, NOD2 and crohn’s disease

Brain O. and Simmons A., (2015), 185 - 196

HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

Heap GA. et al, (2014), Nat Genet, 46, 1131 - 1134

RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.

Colak E. et al, (2014), J Immunol, 192, 5963 - 5973

The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing.

Kennedy NA. et al, (2014), PLoS One, 9

Prioritisation and network analysis of Crohn's disease susceptibility genes.

Muraro D. et al, (2014), PLoS One, 9

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

Lee JC. et al, (2013), Cell, 155, 57 - 69

The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

Brain O. et al, (2013), Immunity, 39, 521 - 536

Intestinal stromal cells in mucosal immunity and homeostasis.

Owens BMJ. and Simmons A., (2013), Mucosal Immunol, 6, 224 - 234

CD90(+) Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa.

Owens BMJ. et al, (2013), Front Immunol, 4

ntigen-sensitive CD8 T-cell clones with tough HIV-1 suppression

Glanville JM. et al, (2013), LANCET, 381, 44 - 44

Understanding Medical Research The Studies That Shaped Medicine

Simmons A. and Pichulik T., (2012)

Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's disease.

Brain O. et al, (2012), Inflamm Bowel Dis, 18, 778 - 781

Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky DJ. et al, (2012), Autophagy, 8, 445 - 544

The impact of NOD2 3020insC mutation in microbial-driven host innate immunity

Milioris E. et al, (2012), IMMUNOLOGY, 137, 535 - 536

Human stromal cell function in chronic intestinal inflammation

Owens BMJ. and Simmons A., (2012), IMMUNOLOGY, 137, 77 - 77

Identification of novel NOD2-regulated proteins using phosphoproteomics

Steevels TAM. et al, (2012), IMMUNOLOGY, 137, 290 - 290

NOD2 function in Crohn's disease.

Simmons A., (2011), J Transl Med, 9 Suppl 2

The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.

Ranasinghe SRF. et al, (2011), PLoS Pathog, 7

The Antiviral Efficacy of HIV-Specific CD8+ T-Cells to a Conserved Epitope is Heavilydependent on the Infecting HIV-1 Isolate

Ranasinghe SRF. et al, (2011), PLoS Pathogens, 7

NOD2 REGULATION OF MICRORNAS

Brain O. et al, (2011), GUT, 60, A37 - A37

Early Phosphorylation Events Induced in Dendritic Cells by the HIV Derived TLR8 Ligand ssRNA40

Leslie AJ. et al, (2011), AIDS RESEARCH AND HUMAN RETROVIRUSES, 27, A65 - A66

Regulation of MicroRNAs by NOD2

Brain O. et al, (2011), GASTROENTEROLOGY, 140, S488 - S488

NOD2 SIGNALLING IN CROHN'S DISEASE

Allan P. et al, (2011), GUT, 60, A63 - A63

Human stromal cell function in chronic intestinal inflammation

Owens BMJ. and Simmons A., (2011), IMMUNOLOGY, 135, 49 - 49

Crohn's disease: Genes, viruses and microbes.

Simmons A., (2010), Nature, 466, 699 - 700

Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection.

Kramer HB. et al, (2010), PLoS Pathog, 6

Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection

Kramer HB. et al, (2010), PLoS Pathogens, 6, 1 - 12

NOD2-mediated autophagy and Crohn disease.

Brain O. et al, (2010), Autophagy, 6, 412 - 414

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.

Cooney R. et al, (2010), Nat Med, 16, 90 - 97

Investigation of NOD2 Signaling in Dendritic Cells

Brain O. et al, (2009), GASTROENTEROLOGY, 136, A249 - A249

ctivation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication.

Hodges A. et al, (2007), Nat Immunol, 8, 569 - 577

Phase I clinical trial safety of DNA- and modified virus Ankara-vectored human immunodeficiency virus type 1 (HIV-1) vaccines administered alone and in a prime-boost regime to healthy HIV-1-uninfected volunteers.

Cebere I. et al, (2006), Vaccine, 24, 417 - 425

Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

Simmons A. et al, (2005), Immunity, 23, 621 - 634

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.

Simmons A. et al, (2001), Immunity, 14, 763 - 777

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