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Research by Prof Andrew Wilkie and Prof Anne Goriely, published in PNAS, has identified the origins of some severe disease-causing mutations within the testicles of normal men. Particular mutations in the FGFR2 gene and a few other disease genes enable the mutated spermatogonia to produce not just sperm but extra copies of themselves, reproducing and spreading faster than the surrounding normal spermatogonia. This tumour-like growth means that over time, a greater proportion of sperm being produced carry disease-causing mutations, increasing the risk of fathering a child with a serious condition.
Bethan Psaila
MRC MHU NDCLS Principal Investigators WIMM
MA; MBBS; MRCP; FRCPath; PhD Bethan Psaila - Associate Professor of Haematology
Paresh Vyas
MRC MHU NDCLS OCH Principal Investigators WIMM
MRCP FRCP FRCPath Paresh Vyas - Professor of Haematology
Christian Babbs
MRC MHU MRC TIDU NDCLS Principal Investigators Research Support WIMM
BSc (Hons) DPhil Christian Babbs - Head of Genome Engineering/Principal Investigator in RDM
Adam Mead
MRC MHU NDCLS Principal Investigators WIMM
PhD MRCP FRCPath Adam Mead - Professor of Haematology
Chris Groves
Administration IMD MRC MHU Research Support WIMM
BSc (Hons) Chris Groves - MRC MHU Laboratory Manager
Daniel North
MRC MHU Researchers Students WIMM
Daniel North - Clinical Research Fellow and DPhil Student
Hana Mlcochova
MRC MHU NDCLS Researchers
PhD Hana Mlcochova - Research Assistant in Medical Genetics
Noemi Roy
MRC MHU NDCLS Researchers
MBChB; BSc; DPhil; MRCP; FRCPath Noemi Roy - Associate Professor of Molecular Haematology