The collaboration has led to the first pre-clinical model of acute erythroid leukaemia.
Acute erythroid leukemia commonly involves both myeloid and erythroid lineage transformation. Di Genua et al. show that combined Cebpa and Gata2 mutations induce bi-lineage AEL. The Gata2 mutation (bottom soil layer) increases chromatin accessibility of erythroid transcription factor motifs (red roots) and decreases chromatin accessibility of myeloid transcription factor motifs (blue roots) while bi-allelic Cebpa mutation (top soil layer) increases erythroid transcription factor expression. This transforms neutrophil-monocyte progenitors into bi-potent leukemia-initiating cells that produce both myeloid and erythroid blasts (red and blue flowers, respectively). Artwork by Rae Cook.
MRC MHU
NDCLS
Researchers
Matthew Gosden - DPhil Student
MRC MHU
NDCLS
Researchers
BSc, MSc Marlen Metzner - Next Generation Sequencing Lead
Administration
Associate CIPD Carol Eaton - MRC WIMM HR Manager
IMD
Students
MD, MSc Amina Ismaeel - DPhil Student
MRC MHU
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Researchers
PhD, Dipl-Biol. Jana Koth - Imaging Facility Manager
NDCLS
Students
Martin Larke - Post Doctoral Researcher
MRC MHU
NDCLS
Researchers
PhD Hana Mlcochova - Research Assistant in Medical Genetics
MRC MHU
NDCLS
Researchers
PhD Ruggiero Norfo - Postdoctoral researcher
Research Support
MSc; PhD Emmanouela Repapi - UKRI Rutherford Fund Fellow
IMD
Researchers
BSc (Hons); MRes; PhD Rachel Rigby - Postdoctoral Scientist
MRC MHU
NDCLS
Researchers
MBChB; BSc; DPhil; MRCP; FRCPath Noemi Roy - Associate Professor of Molecular Haematology
MRC MHU
NDCLS
Researchers
BSc (Hons); PhD Caroline Scott - Research Assistant
IMD
Students
Julie Xiao - DPhil Student
MRC MHU
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PhD; BSc (Hons) Yan Zhou - Postdoctoral Researcher
MRC MHU
NDCLS
Students
DPhil Lance Hentges - Postdoctoral Scientist
IMD
Students
Johannes Pettmann - DPhil Student
IMD
Researchers
PhD, MSc, BSc (Hons) Randeep Singh - Postdoctoral Scientist
IMD
Researchers
Xi Li - Postdoctoral Scientist
IMD
Students
Xiaopeng Fu - DPhil Student
MRC MHU
NDCLS
Researchers
Priscila Hirschfeld
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