The collaboration has led to the first pre-clinical model of acute erythroid leukaemia.
Acute erythroid leukemia commonly involves both myeloid and erythroid lineage transformation. Di Genua et al. show that combined Cebpa and Gata2 mutations induce bi-lineage AEL. The Gata2 mutation (bottom soil layer) increases chromatin accessibility of erythroid transcription factor motifs (red roots) and decreases chromatin accessibility of myeloid transcription factor motifs (blue roots) while bi-allelic Cebpa mutation (top soil layer) increases erythroid transcription factor expression. This transforms neutrophil-monocyte progenitors into bi-potent leukemia-initiating cells that produce both myeloid and erythroid blasts (red and blue flowers, respectively). Artwork by Rae Cook.
MRC MHU
NDCLS
Principal Investigators
WIMM
MA; MBBS; MRCP; FRCPath; PhD Bethan Psaila - Associate Professor of Haematology
MRC MHU
Students
Eva Thielecke - Visiting Student
MRC MHU
NDCLS
OCH
Principal Investigators
WIMM
MRCP FRCP FRCPath Paresh Vyas - Professor of Haematology
MRC MHU
MRC TIDU
NDCLS
Principal Investigators
Research Support
WIMM
BSc (Hons) DPhil Christian Babbs - Head of Genome Engineering/Principal Investigator in RDM
MRC MHU
NDCLS
Researchers
Matthew Gosden - DPhil Student
MRC MHU
NDCLS
Principal Investigators
WIMM
PhD MRCP FRCPath Adam Mead - Professor of Haematology
MRC MHU
NDCLS
Principal Investigators
WIMM
PhD Thomas Milne - Professor of Haematology
MRC MHU
NDCLS
Researchers
BSc, MSc Marlen Metzner - Next Generation Sequencing Lead
Administration
IMD
MRC MHU
Research Support
WIMM
BSc (Hons) Chris Groves - MRC MHU Laboratory Manager
MRC MHU
NDCLS
Researchers
WIMM
Verena Korber - Postdoctoral Fellow
MRC MHU
Researchers
Students
WIMM
Daniel North - Clinical Research Fellow and DPhil Student
MRC MHU
Students
WIMM
BA (Hons) Natural Sciences Abhimanyu Gowda - DPhil Student
MRC MHU
NDCLS
Researchers
PhD, Dipl-Biol. Jana Koth - Imaging Facility Manager
MRC MHU
NDCLS
Researchers
PhD Hana Mlcochova - Research Assistant in Medical Genetics
MRC MHU
NDCLS
Researchers
PhD Ruggiero Norfo - Postdoctoral researcher
MRC MHU
NDCLS
Researchers
MBChB; BSc; DPhil; MRCP; FRCPath Noemi Roy - Associate Professor of Molecular Haematology
MRC MHU
NDCLS
Researchers
BSc (Hons); PhD Caroline Scott - Research Assistant
MRC MHU
NDCLS
Researchers
PhD; BSc (Hons) Yan Zhou - Postdoctoral Researcher
MRC MHU
NDCLS
Researchers
WIMM
Yavor Bozhilov - Postdoctoral Researcher
MRC MHU
NDCLS
Students
DPhil Lance Hentges - Postdoctoral Scientist
Load More