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Found 446 matches for

The collaboration has led to the first pre-clinical model of acute erythroid leukaemia.

Acute erythroid leukemia commonly involves both myeloid and erythroid lineage transformation. Di Genua et al. show that combined Cebpa and Gata2 mutations induce bi-lineage AEL. The Gata2 mutation (bottom soil layer) increases chromatin accessibility of erythroid transcription factor motifs (red roots) and decreases chromatin accessibility of myeloid transcription factor motifs (blue roots) while bi-allelic Cebpa mutation (top soil layer) increases erythroid transcription factor expression. This transforms neutrophil-monocyte progenitors into bi-potent leukemia-initiating cells that produce both myeloid and erythroid blasts (red and blue flowers, respectively). Artwork by Rae Cook.
Acute erythroid leukemia commonly involves both myeloid and erythroid lineage transformation. Di Genua et al. show that combined Cebpa and Gata2 mutations induce bi-lineage AEL. The Gata2 mutation (bottom soil layer) increases chromatin accessibility of erythroid transcription factor motifs (red roots) and decreases chromatin accessibility of myeloid transcription factor motifs (blue roots) while bi-allelic Cebpa mutation (top soil layer) increases erythroid transcription factor expression. This transforms neutrophil-monocyte progenitors into bi-potent leukemia-initiating cells that produce both myeloid and erythroid blasts (red and blue flowers, respectively). Artwork by Rae Cook.

New heart disease calculator could save lives by identifying high-risk patients missed by current tools

CVM Department General

Collaborative research, led from NDPCHS and published today in Nature Medicine, has developed a new tool called QR4 that more accurately predicts an individual's 10-year risk of cardiovascular diseases, like heart disease and stroke, particularly identifying high-risk patients that current prediction tools miss.

Wellcome Career Development Awards for Betty Raman and Adam Wilkinson

Awards CVM Department MRC WIMM

Associate Professors Betty Raman and Adam Wilkinson have both won an eight-year Wellcome Career Development Award to further their research.

Study will assess new MRI technique to detect liver cancer

CVM Department OCMR

The DeLIVER team will evaluate non-contrast-enhanced MRI and compare it to standard of care ultrasound in a cohort of patients under surveillance for liver cancer.

RDM early career researchers shine in Parliamentary scientific poster competition

Awards Department General

Organised by the Parliamentary & Scientific Committee, STEM for BRITAIN is a major scientific poster competition and exhibition, held annually at the Houses of Parliament.

Professor Rury Holman wins 2024 Banting Medal for Scientific Achievement

Awards DTU Department General OCDEM

The American Diabetes Association (ADA) has announced this year's National Scientific and Health Care Achievement Award recipients.

New study provides framework for optimising the design of antibody therapeutics

Department General MRC TIDU Publication Research

Dr Zakariye Ashkir wins CMR 2024 Early Career Award

Awards CVM Department General OCMR

World Cancer Day 2024: Highlighting cancer research at the MRC WIMM

Department General MRC MHU MRC WIMM Research

This World Cancer Day, we heard from four Group Leaders at the MRC Weatherall Institute of Molecular Medicine about their work and how their groups are helping in the fight against cancer.

Prof Leanne Hodson appointed new Divisional Advocate for Research Staff

Department General OCDEM Research

New Cross-Cutting Research Theme Lead for Biomedical Metabolism

Department General IMD MRC WIMM Research

Researchers define new class of regulatory element in DNA

Department MRC WIMM Publication Research

Race to cure type 1 diabetes gets a new boost

Department General OCDEM Research

RDM group awarded £2.55 million for diabetes research.

Welcome to the new RDM Visiting Professors

Department General IMD

Diabetes UK visits OCDEM labs

Department General OCDEM Research

AI tool could help thousands avoid fatal heart attacks

AMIIC CVM Department General Publication Research

An Artificial Intelligence (AI) tool that can predict 10-year risk of deadly heart attacks, could transform treatment for patients who undergo CT scans to investigate chest pain, according to British Heart Foundation (BHF)-funded research presented at the American Heart Association’s Scientific Sessions in Philadelphia.

Heart attack risk decreased in new mothers by self-monitoring blood pressure at home

CCRF CVM Department General Publication Research

Self-monitoring blood pressure after giving birth could help to cut new mothers’ risk of future heart disease and strokes, according to new research by Oxford researchers.

Professor David Sims receives Major Educator Award

Awards Department MRC WIMM

Associate Professor David Sims has received the Major Educator Award as part of the 2023 Medical Sciences Division Teaching Excellence Awards.

Single cell spatial analysis provides new insight into immune-pathology in Covid-19 lungs

COVID-19 research Department MRC TIDU MRC WIMM Publication Research

Congratulations to our new PIs

Department General

Emeritus Professor David Jackson receives Lifetime Achievement Awards

Awards Department General MRC TIDU MRC WIMM

Professor David Jackson has been awarded the Rooster Prize by the International Society for Hyaluronan Sciences (ISHAS) and the Gasparo Aselli Medal by the International Society of Lymphology (ISL).

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